Humphreys Ruth E, Green Daniel J, Cable N Timothy, Thijssen Dick H J, Dawson Ellen A
Research Institute for Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK.
Expert Rev Cardiovasc Ther. 2014 May;12(5):557-64. doi: 10.1586/14779072.2014.909728. Epub 2014 Apr 18.
Given the prevalence of cardiovascular disease (CVD), early detection is crucial. Although traditional cardiovascular risk factors relate to future CVD, the predictive value of these risk factors can be relatively limited. Contemporary scientific attention has focused on alternative direct measures of arterial function. Based on the ability of the endothelium to acutely dilate in response to an increase in flow, 'flow mediated dilation' (FMD) was introduced approximately 20 years ago and is now an established non-invasive index of endothelial function predictive of future cardiovascular events. Recently, 'low-flow mediated constriction' (L-FMC) has been proposed as a complementary addition to FMD. The technique is based on the constrictor response to decreased flow and is claimed to improve the sensitivity and specificity of FMD. The aim of this review is to examine literature pertaining to this novel technique and to provide insight into the potential use of L-FMC in future research.
鉴于心血管疾病（CVD）的普遍性，早期检测至关重要。尽管传统的心血管危险因素与未来的心血管疾病相关，但这些危险因素的预测价值可能相对有限。当代科学关注已聚焦于动脉功能的替代直接测量方法。基于内皮对血流增加做出急性扩张的能力，“血流介导的扩张”（FMD）大约在20年前被引入，现在是预测未来心血管事件的内皮功能的既定非侵入性指标。最近，“低血流介导的收缩”（L-FMC）已被提议作为FMD的补充。该技术基于对血流减少的收缩反应，据称可提高FMD的敏感性和特异性。本综述的目的是研究与这项新技术相关的文献，并深入了解L-FMC在未来研究中的潜在用途。
