Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Department of Women's Health, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Nutrients. 2019 Nov 20;11(12):2844. doi: 10.3390/nu11122844.
This study aimed to investigate the effects of grape seed proanthocyanidin extract (GSPE) on blood pressure and vascular endothelial function in middle-aged Japanese adults with prehypertension. We conducted a randomized, double-blind, placebo-controlled study on 6 men and 24 women aged 40-64 years old. The participants were randomized to receive tablets containing either low-dose (200 mg/day) or high-dose (400 mg/day) GSPE, or placebo, for 12 weeks. Systolic and diastolic blood pressures (SBP and DBP, respectively), brachial flow-mediated dilation (FMD), and other cardiovascular parameters were measured before and after 4, 8, and 12 weeks of treatment. The mean SBP in the high-dose group significantly decreased by 13 mmHg after 12 weeks ( = 0.028), although FMD did not change. In an ad hoc analysis of non-smoking participants ( = 21), the mean SBP, DBP, stiffness parameter β, distensibility, incremental elastic modulus (Einc), and pulse wave velocity (PWV) also significantly improved in the high-dose group after 12 weeks. Changes in Einc and PWV from baseline to 12 weeks were significantly greater in the high-dose group than in the placebo group (Einc, = 0.023; PWV, = 0.03). GSPE consumption could help maintain vascular elasticity and normal blood pressure in this population.
本研究旨在探讨葡萄籽原花青素提取物（GSPE）对中年日本高血压前期人群血压和血管内皮功能的影响。我们对 6 名男性和 24 名年龄在 40-64 岁的女性进行了一项随机、双盲、安慰剂对照研究。参与者随机接受低剂量（200mg/天）或高剂量（400mg/天）GSPE 片剂或安慰剂，治疗 12 周。在治疗 4、8 和 12 周前后测量收缩压和舒张压（SBP 和 DBP）、肱动脉血流介导的扩张（FMD）和其他心血管参数。高剂量组的平均 SBP 在 12 周后显著下降 13mmHg（ = 0.028），尽管 FMD 没有变化。在非吸烟参与者的专门分析中（ = 21），高剂量组的平均 SBP、DBP、僵硬参数β、扩张性、增量弹性模量（Einc）和脉搏波速度（PWV）在 12 周后也显著改善。从基线到 12 周，高剂量组的 Einc 和 PWV 变化明显大于安慰剂组（Einc， = 0.023；PWV， = 0.03）。GSPE 的摄入可能有助于维持该人群的血管弹性和正常血压。
