[中国八个省份普通人群尿液中多环芳烃单羟基代谢物水平]
[Polycyclic aromatic hydrocarbons monohydroxy metabolites level in urine of general population in eight provinces of China].
作者信息
Huang Chuanfeng, Zhang Jing, Ding Chunguang, Liu Cuilan, Wang Gang, Song Xinkui, Huang Hanlin, Zhu Baoli, Shao Hua, Zhao Chunxiang, Han Changcheng, Peng Shanzhuo, Jiang Xianlong, Yu Shanfa, Ji Hongrong, Zhang Xiaoxi, Sun Ran, Zheng Yuxin, Yan Huifang
机构信息
Key Laboratory of Chemical Safety and Health,National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
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出版信息
Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Feb;48(2):102-8.
OBJECTIVE
To assess the levels of polycyclic aromatic hydrocarbons monohydroxy metabolites in urine of general population in China among 8 provinces, provide the baseline of the metabolites in the general population.
METHODS
From 2009 to 2010, 18 120 subjects of general population aged 6-60 years old were recruited from 24 areas among 8 provinces in east, west and central areas of China mainland by cluster random sampling. The information of the living environment and health condition were collected by questionnaire and spot urine samples were collected, 4 680 urine samples were analysed by high performance liquid chromatography with tandem mass spectrometry, and monohydroxy metabolites distribution in urine among groups of gender and ages were analysed.
RESULTS
Geometric means (GM) of 2-naphthol, 1-naphthol, 3-phenanthrol and 1-hydroxypyrene concentration in urine (95%CI) were 1.85 (1.75-1.95), 1.55 (1.50-1.61), 0.57 (0.54-0.59) and 0.82 (0.78-0.85) µg/L, respectively;and median are 2.44, <0.50, 0.72 and 0.90 µg/L, respectively. The concentration between male and female were significantly different (P < 0.01), and the concentration among the groups of population were significantly different (P < 0.01), the GM of 2-naphthol among the groups of population aged 6-12, 13-16, 17-20, 21-30, 31-45 and 46-60 years old were 1.60, 1.56, 1.69, 2.23, 1.91 and 1.86 µg/L (χ(2) = 17.90, P < 0.01), the GM of 1-naphthol in the groups were 1.30, 1.16, 1.53, 1.68, 1.80 and 1.52 µg/L (χ(2) = 76.22, P < 0.01), the GM of 3-phenanthrol in the groups were 0.78, 0.76, 0.55, 0.42, 0.50 and 0.99 µg/L (χ(2) = 66.48, P < 0.01), the GM of 1-hydroxypyrene in the groups were 0.77,0.64, 1.00, 0.84, 0.84 and 0.57 µg/L (χ(2) = 51.48, P < 0.01), respectively.
CONCLUSION
The distribution of monohydroxy metabolites levels in urine of general population were different, it provided a basic data for the further study of polycyclic aromatic hydrocarbons biomonitoring in the population.
目的
评估中国8个省份普通人群尿液中多环芳烃单羟基代谢物的水平，提供普通人群中这些代谢物的基线数据。
方法
2009年至2010年，通过整群随机抽样从中国大陆东部、西部和中部8个省份的24个地区招募了18120名6至60岁的普通人群受试者。通过问卷调查收集生活环境和健康状况信息，并采集即时尿样，4680份尿样采用高效液相色谱串联质谱法进行分析，分析尿中单羟基代谢物在性别和年龄组中的分布情况。
结果
尿中2-萘酚、1-萘酚、3-菲酚和1-羟基芘浓度的几何均值（GM）（95%CI）分别为1.85（1.75 - 1.95）、1.55（1.50 - 1.61）、0.57（0.54 - 0.59）和0.82（0.78 - 0.85）μg/L；中位数分别为2.44、<0.50、0.72和0.90μg/L。男性和女性之间的浓度有显著差异（P < 0.01），不同人群组之间的浓度也有显著差异（P < 0.01），6至12岁、13至16岁、17至20岁、21至30岁、31至45岁和46至60岁人群组中2-萘酚的GM分别为1.60、1.56、1.69、2.23、1.91和1.86μg/L（χ(2) = 17.90，P < 0.01），1-萘酚在各年龄组中的GM分别为1.30、1.16、1.53、1.68、1.80和1.52μg/L（χ(2) = 76.22，P < 0.01），3-菲酚在各年龄组中的GM分别为0.78、0.76、0.55、0.42、0.50和0.99μg/L（χ(2) = 66.48，P < 0.01），1-羟基芘在各年龄组中的GM分别为0.77、0.64、1.00、0.84、0.84和0.57μg/L（χ(2) = 51.48，P < 0.01）。
结论
普通人群尿液中单羟基代谢物水平的分布存在差异，为进一步开展人群多环芳烃生物监测研究提供了基础数据。
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