Pan Yajuan, Ding Chunguang, Zhang Aihua, Wu Banghua, Huang Hanlin, Zhu Chun, Liu Deye, Zhu Baoli, Xu Guang, Shao Hua, Peng Shanzhuo, Jiang Xianlong, Zhao Chunxiang, Han Changcheng, Ji Hongrong, Yu Shanfa, Zhang Xiaoxi, Zhang Longlian, Zheng Yuxin, Yan Huifang
National Institute of Occupational Health and Poison Control, China Center for Disease Control and Prevention, Beijing 100050, China.
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Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Sep;48(9):784-90.
To evaluated the manganese (Mn), cobalt (Co) and molybdenum (Mo) levels in blood and urine among general population in China, and thereby to analyze their prevalent features.
From 2009 to 2010, a total of 18 120 subjects of general population aged 6-60 years were recruited from 24 districts in 8 provinces in eastern, central and western China mainland, by cluster random sampling method. The information about their living environment and health status were collected by questionnaire, and their blood and urine samples were also collected.Inductive coupled plasma mass spectrometry (ICP-MS) was applied to test the Mn, Co and Mo levels of blood and urine samples, and the Mn, Co, Mo distribution in blood and urine among groups of population in different ages and genders were then analyzed.
Among general population in China, the geometric mean (GM) of Mn concentration in blood was 8.98 µg/L. The Mn concentration in blood among males and females were separately 8.14 µg/L and 9.88 µg/L (Z = -18.84, P < 0.01). The GM of Mn concentration in urine was 0.63 µg/L. The Mn concentration in urine among males and females were separately 0.62 µg/L and 0.63 µg/L (Z = -0.67, P > 0.05). The geometric mean (GM) of Co concentration in blood was 0.194 µg/L. The Co concentration in blood among males and females were separately 0.166 µg/L and 0.225 µg/L (Z = -23.04, P < 0.01). The GM of Co concentration in urine was 0.282 µg/L. The Co concentration in urine among males and females were separately 0.260 µg/L and 0.307 µg/L (Z = -7.35, P < 0.01). The GM of Mo concentration in blood was 0.25 µg/L. The Mo concentration in blood among male and female group were separately 0.27 µg/L and 0.23 µg/L (Z = -5.03, P < 0.01). The GM of Mo concentration in urine was 27.7 µg/L. The Mo concentration in urine among males and females were 29.8 µg/L and 25.6 µg/L (Z = -6.31, P < 0.01), respectively.
The Mn, Co and Mo levels in blood and urine varied by gender and area among general population in China, the study provided basic data evidence for the following Mn, Co and Mo biological monitoring studies in near future.
评估中国普通人群血液和尿液中的锰（Mn）、钴（Co）和钼（Mo）水平，进而分析其流行特征。
2009年至2010年，采用整群随机抽样方法，从中国大陆东部、中部和西部8个省份的24个地区招募了18120名6至60岁的普通人群。通过问卷调查收集其生活环境和健康状况信息，并采集血液和尿液样本。采用电感耦合等离子体质谱法（ICP-MS）检测血液和尿液样本中的Mn、Co和Mo水平，然后分析不同年龄和性别人群组中血液和尿液中Mn、Co、Mo的分布情况。
在中国普通人群中，血液中Mn浓度的几何均值（GM）为8.98μg/L。男性和女性血液中的Mn浓度分别为8.14μg/L和9.88μg/L（Z = -18.84，P < 0.01）。尿液中Mn浓度的GM为0.63μg/L。男性和女性尿液中的Mn浓度分别为0.62μg/L和0.63μg/L（Z = -0.67，P > 0.05）。血液中Co浓度的几何均值（GM）为0.194μg/L。男性和女性血液中的Co浓度分别为0.166μg/L和0.225μg/L（Z = -23.04，P < 0.01）。尿液中Co浓度的GM为0.282μg/L。男性和女性尿液中的Co浓度分别为0.260μg/L和0.307μg/L（Z = -7.35，P < 0.01）。血液中Mo浓度的GM为0.25μg/L。男性和女性组血液中的Mo浓度分别为0.27μg/L和0.23μg/L（Z = -5.03，P < 0.01）。尿液中Mo浓度的GM为27.7μg/L。男性和女性尿液中的Mo浓度分别为29.8μg/L和25.6μg/L（Z = -6.31，P < 0.01）。
中国普通人群血液和尿液中的Mn、Co和Mo水平因性别和地区而异，该研究为今后开展Mn、Co和Mo生物监测研究提供了基础数据依据。
