Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A *STAR), 11 Biopolis Way, 138667, Singapore.
Nanomedicine (Lond). 2014 Mar;9(3):523-35. doi: 10.2217/nnm.13.222.
The advancement of surface-enhanced Raman scattering (SERS) is significantly increasing as an ultra-sensitive sensing technology in biomedical research. In this review, we focus on the most recent developments of biocompatible nanoprobes for cancer research. First, we discuss coating approaches to enhance the biocompatibility of SERS substrate and Raman reporters. Furthermore, interesting ligands such as antibodies, aptamers and polypeptides are attached to the surface of nanotags for targeting the cancerous cells in vitro. The unique multiplexing capabilities of the SERS technique have been applied for simultaneous multiple target recognition. Finally, these noninvasive, ultrasensitive tools are mostly highlighted for in vivo tumor detection. Potential application of SERS nanotags in therapeutic study and the possibility of SERS nanotags in biomedical applications are outlined briefly in this review.
表面增强拉曼散射（SERS）技术作为一种超灵敏的生物医学研究传感技术，其发展得到了显著提升。在这篇综述中，我们专注于用于癌症研究的生物相容性纳米探针的最新进展。首先，我们讨论了增强 SERS 基底和拉曼报告分子的生物相容性的涂层方法。此外，有趣的配体，如抗体、适体和多肽，被连接到纳米标签的表面，用于体外靶向癌细胞。SERS 技术的独特多重分析能力已被应用于同时进行多种靶标识别。最后，这些非侵入性、超高灵敏度的工具主要用于体内肿瘤检测。在本文的综述中，简要概述了 SERS 纳米标签在治疗研究中的潜在应用和在生物医学应用中的可能性。
