神经病理学对人类和实验性颞叶癫痫中脑炎症的影响。
The influence of neuropathology on brain inflammation in human and experimental temporal lobe epilepsy.
机构信息
School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
School for Mental Health & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; Department of Neurosurgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
出版信息
J Neuroimmunol. 2014 Jun 15;271(1-2):36-42. doi: 10.1016/j.jneuroim.2014.03.016. Epub 2014 Mar 29.
It is unclear to what extent neuropathological changes contribute to brain inflammation observed in temporal lobe epilepsy (TLE). Here, we compared cytokine levels between histopathologically-confirmed sclerotic hippocampi and histopathologically-confirmed normal hippocampi from TLE patients. We analyzed a similar cytokine panel in the hippocampi of amygdala-kindled rats and we evaluated neuropathological changes by immunohistochemistry. In TLE patients, cytokine levels were not significantly different between sclerotic and non-sclerotic hippocampi. Though kindling resulted in increased astrocyte activation, cytokine levels and microglia activation were unchanged. These results suggest that the chronic epileptic state in TLE can also occur in the absence of intracerebral inflammation. Highlights.
神经病理学变化在多大程度上导致颞叶癫痫（TLE）中观察到的脑炎症尚不清楚。在这里，我们比较了经组织病理学证实的硬化海马和 TLE 患者的经组织病理学证实的正常海马中的细胞因子水平。我们分析了杏仁核点燃大鼠海马中的类似细胞因子谱，并通过免疫组织化学评估了神经病理学变化。在 TLE 患者中，硬化和非硬化海马之间的细胞因子水平没有显着差异。尽管点燃导致星形胶质细胞激活增加，但细胞因子水平和小胶质细胞激活没有改变。这些结果表明，TLE 中的慢性癫痫状态也可能在没有颅内炎症的情况下发生。
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