Luo Qiong, Li Jingjing, Cui Xiaoyan, Yan Jun, Zhao Qihan, Xiang Chunyan
Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, PR China.
Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, PR China.
J Ethnopharmacol. 2014 May 28;154(1):249-58. doi: 10.1016/j.jep.2014.04.013. Epub 2014 Apr 16.
Lycium barbarum, a Solanaceous defoliated shrubbery, has been used as a kind of traditional Chinese herbal medicines for thousands of years. Lycium barbarum polysaccharide (LBP) is the main bioactive component of Lycium barbarum. The aim of this study was to investigate the radioresistant effect of LBP on the damage of male rats' reproductive system and spermatogenic cells caused by low-dose (60)Co-γ irradiation.
Male rats were randomly divided into 7 groups and treated with irradiation and/or LBP: normal control group, irradiation control group 1, irradiation control group 2, irradiation control group 3, LBP + irradiation group 1, LBP + irradiation group 2, and LBP + irradiation group 3.
It is found that mating function and testis organ coefficient in LBP + irradiation groups were significantly better than that of the corresponding irradiation control groups. LBP significantly up-regulates the expression of Bcl-2 while down-regulating the expression of Bax. And LBP also plays an important role in prevention mitochondrial membrane potential decrease. In addition, LBP can significantly reduce spermatogenic cells apoptosis.
LBP has obvious protective effect on the male rats' reproductive function and spermatogenic dysfunction induced by irradiation.
枸杞，一种茄科落叶灌木，数千年来一直被用作一种传统中药。枸杞多糖（LBP）是枸杞的主要生物活性成分。本研究的目的是探讨LBP对低剂量（60）Co-γ辐射所致雄性大鼠生殖系统和生精细胞损伤的抗辐射作用。
将雄性大鼠随机分为7组，分别进行辐射和/或LBP处理：正常对照组、辐射对照组1、辐射对照组2、辐射对照组3、LBP+辐射组1、LBP+辐射组2和LBP+辐射组3。
发现LBP+辐射组的交配功能和睾丸器官系数明显优于相应的辐射对照组。LBP显著上调Bcl-2的表达，同时下调Bax的表达。并且LBP在预防线粒体膜电位降低方面也起着重要作用。此外，LBP可显著减少生精细胞凋亡。
LBP对辐射所致雄性大鼠生殖功能和生精功能障碍具有明显的保护作用。
