Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Trends Endocrinol Metab. 2014 May;25(5):225-34. doi: 10.1016/j.tem.2014.03.010. Epub 2014 Apr 17.
Autophagy (or 'self-eating') is the process by which cellular contents are recycled to support downstream metabolism. An explosion in research in the past decade has implicated its role in both health and disease and established the importance of the autophagic response during periods of stress and nutrient deprivation. Atherosclerosis is a state where chronic exposure to cellular stressors promotes disease progression, and alterations in autophagy are predicted to be consequential. Recent reports linking macrophage autophagy to lipid metabolism, blunted inflammatory signaling, and an overall suppression of proatherogenic processes support this notion. We review these data and provide a framework for understanding the role of macrophage autophagy in the pathogenesis of atherosclerosis, one of the most formidable diseases of our time.
自噬（或“自我吞噬”）是细胞内容物被回收以支持下游代谢的过程。在过去十年中，研究的爆炸式增长表明自噬在健康和疾病中都发挥了作用，并确定了在应激和营养缺乏期间自噬反应的重要性。动脉粥样硬化是一种慢性暴露于细胞应激原促进疾病进展的状态，并且自噬的改变预计是有后果的。最近有报道将巨噬细胞自噬与脂质代谢、炎症信号转导减弱以及促动脉粥样硬化过程的整体抑制联系起来，支持了这一观点。我们回顾了这些数据，并为理解巨噬细胞自噬在动脉粥样硬化发病机制中的作用提供了一个框架，动脉粥样硬化是我们这个时代最可怕的疾病之一。
