评估线粒体DNA变异在辐射诱导毒性遗传易感性中的作用。
Evaluating the role of mitochondrial DNA variation to the genetic predisposition to radiation-induced toxicity.
作者信息
Fachal Laura, Mosquera-Miguel Ana, Gómez-Caamaño Antonio, Sánchez-García Manuel, Calvo Patricia, Lobato-Busto Ramón, Salas Antonio, Vega Ana
机构信息
Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS, Santiago de Compostela, Spain.
Unidade de Xenética, Instituto de Ciencias Forenses and Departamento de Anatomía Patolóxica e Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Galicia, Spain.
出版信息
Radiother Oncol. 2014 May;111(2):199-205. doi: 10.1016/j.radonc.2014.03.012. Epub 2014 Apr 17.
BACKGROUND AND PURPOSE
Mitochondrial DNA common variants have been reported to be associated with the development of radiation-induced toxicity. Using a large cohort of patients, we aimed to validate these findings by investigating the potential role of common European mitochondrial DNA SNPs (mtSNPs) to the development of radio-toxicity.
MATERIAL AND METHODS
Overall acute and late toxicity data were assessed in a cohort of 606 prostate cancer patients by means of Standardized Total Average Toxicity (STAT) score. We carried out association tests between radiation toxicity and a selection of 15 mtSNPs (and the haplogroups defined by them).
RESULTS
Statistically significant association between mtSNPs and haplogroups with toxicity could not be validated in our Spanish cohort.
CONCLUSIONS
The present study suggests that the mtDNA common variants analyzed are not associated with clinically relevant increases in risk of overall radiation-induced toxicity in prostate cancer patients.
背景与目的
线粒体DNA常见变异已被报道与辐射诱导毒性的发生有关。我们利用一大群患者，旨在通过研究常见欧洲线粒体DNA单核苷酸多态性（mtSNP）对放射性毒性发生的潜在作用来验证这些发现。
材料与方法
通过标准化总平均毒性（STAT）评分，对606名前列腺癌患者队列中的总体急性和晚期毒性数据进行评估。我们对辐射毒性与15个mtSNP（以及由它们定义的单倍群）进行了关联测试。
结果
在我们的西班牙队列中，无法验证mtSNP和单倍群与毒性之间具有统计学意义的关联。
结论
本研究表明，所分析的线粒体DNA常见变异与前列腺癌患者总体辐射诱导毒性风险的临床相关增加无关。
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