Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Dev Biol. 2014 Jul 15;391(2):125-32. doi: 10.1016/j.ydbio.2014.04.003. Epub 2014 Apr 16.
Historically, analyses of mesothelial differentiation have focused on the heart where a highly migratory population of progenitors originating from a localized "extrinsic" source moves to and over the developing organ. This model long stood alone as the paradigm for generation of this cell type. Here, using chick/quail chimeric grafting and subsequent identification of mesothelial cell populations, we demonstrate that a different mechanism for the generation of mesothelia exists in vertebrate organogenesis. In this newly discovered model, mesothelial progenitors are intrinsic to organs of the developing digestive and respiratory systems. Additionally, we demonstrate that the early heart stands alone in its ability to recruit an entirely exogenous mesothelial cell layer during development. Thus, the newly identified "organ intrinsic" model of mesotheliogenesis appears to predominate while the long-studied cardiac model of mesothelial development may be the outlier.
从历史上看，间皮分化的分析主要集中在心脏上，那里有一群起源于局部“外在”来源的高迁移性祖细胞迁移并覆盖在发育中的器官上。这个模型长期以来一直是生成这种细胞类型的范例。在这里，我们使用鸡/鹌鹑嵌合体移植和随后对间皮细胞群体的鉴定，证明在脊椎动物器官发生中存在一种不同的间皮生成机制。在这个新发现的模型中，间皮祖细胞是发育中消化和呼吸系统器官的固有组成部分。此外，我们还证明，早期心脏在发育过程中招募完全外生性间皮细胞层的能力是独一无二的。因此，新发现的间皮发生“器官固有”模型似乎占主导地位，而长期研究的心脏间皮发育模型可能是个例外。
