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24 小时内检测产碳青霉烯酶肠杆菌科患者携带情况的新筛选方法。

New screening method to detect carriage of carbapenemase-producing Enterobacteriaceae in patients within 24 hours.

机构信息

Department of Medical Microbiology and Medical Immunology, Rijnstate, Velp, The Netherlands; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Department of Medical Microbiology and Medical Immunology, Rijnstate, Velp, The Netherlands.

出版信息

J Hosp Infect. 2014 May;87(1):47-9. doi: 10.1016/j.jhin.2014.03.003. Epub 2014 Mar 26.

Abstract

Rapid identification of patients colonized with carbapenemase-producing Enterobacteriaceae (CPE) is essential to prevent introduction and the spread of CPE in the hospital. This article presents the results of a new screening method to detect patients colonized with CPE within 24h after hospital admission. From high-risk patients rectal and throat swabs were collected and incubated overnight, after which DNA was isolated and tested for the most prevalent CPE genes (KPC, NDM, OXA-48, VIM and IMP) by a ligation-mediated real-time polymerase chain reaction. In 14 months 454 patients were screened; in six patients CPE were detected (carriage rate 1.3%).

摘要

快速鉴定产碳青霉烯酶肠杆菌科细菌(CPE)定植患者对于防止 CPE 在医院内的引入和传播至关重要。本文介绍了一种新的筛选方法,可在患者入院后 24 小时内检测出 CPE 定植患者。从高风险患者的直肠和咽喉拭子中采集样本并过夜孵育,然后提取 DNA,通过连接介导的实时聚合酶链反应检测最常见的 CPE 基因(KPC、NDM、OXA-48、VIM 和 IMP)。在 14 个月的时间里,对 454 名患者进行了筛查;在 6 名患者中检测到 CPE(携带率为 1.3%)。

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