Matsumoto Naoyuki, Kitano Taiichi, Oki Hidero, Omagari Daisuke, Matsue Yasuyoshi, Okudera Michisato, Yamamura Takashi, Nishikawa Yohichi, Nishimura Satoshi, Asano Masatake, Komiyama Kazuo
Assistant Professor, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
Postgraduate student, Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Sep;118(3):e79-83. doi: 10.1016/j.oooo.2014.01.230. Epub 2014 Feb 6.
Oral melanotic lesions, including melanin pigmentation, melanocytic nevus, and malignant melanoma, are well-recognized pathologic entities. However, melanocytic proliferation within malignant oral mucosal lesions is not well documented. We report the unusual case of a 53-year-old Japanese man who developed oral carcinoma in situ (CIS) with melanocytic proliferation and melanin pigmentation in the epithelial layer. The patient, a nonsmoker and an opportunistic drinker, presented with a brown tongue lesion. Initial examination found a large brown pigmented area and multiple small white patchy areas on the right tongue border. The pigmentation had an ill-defined border with uneven color distribution. Physical examination found no abnormalities. Ultrasonography did not find a deeply infiltrating lesion. Oral mucosal malignant melanoma in situ was diagnosed, and partial tongue resection was performed. Histopathologic examination found oral pigmented CIS. To the best of our knowledge, this is only the third reported case of oral pigmented CIS.
口腔黑色素沉着性病变，包括黑色素沉着、黑素细胞痣和恶性黑色素瘤，是公认的病理实体。然而，恶性口腔黏膜病变中的黑素细胞增殖情况尚无充分记录。我们报告了一例罕见病例，一名53岁的日本男性，其原位口腔癌（CIS）伴有上皮层黑素细胞增殖和黑色素沉着。该患者不吸烟，偶尔饮酒，出现舌部褐色病变。初步检查发现右侧舌缘有一大片褐色色素沉着区和多个小的白色斑块状区域。色素沉着边界不清，颜色分布不均。体格检查未发现异常。超声检查未发现深部浸润性病变。诊断为原位口腔黏膜恶性黑色素瘤，并进行了部分舌切除术。组织病理学检查发现口腔色素沉着性原位癌。据我们所知，这是第三例报告的口腔色素沉着性原位癌病例。
