Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia.
Nat Rev Immunol. 2012 Jan 25;12(2):101-13. doi: 10.1038/nri3149.
Specialized subsets of dendritic cells (DCs) provide a crucial link between the innate and adaptive immune responses. The genetic programme that coordinates these distinct DC subsets is controlled by both cytokines and transcription factors. The initial steps in DC specification occur in the bone marrow and result in the generation of precursors committed to either the plasmacytoid or conventional DC pathways. DCs undergo further differentiation and lineage diversification in peripheral organs in response to local environmental cues. In this Review, we discuss new evidence regarding the coordination of the specification and commitment of precursor cells to different DC subsets and highlight the ensemble of transcription factors that control these processes.
树突状细胞 (DCs) 的特化亚群在先天免疫和适应性免疫反应之间提供了至关重要的联系。协调这些不同 DC 亚群的遗传程序受细胞因子和转录因子的控制。DC 特异性的初始步骤发生在骨髓中，导致生成定向于浆细胞样或常规 DC 途径的前体细胞。DC 在外周器官中进一步分化和谱系多样化，以响应局部环境线索。在这篇综述中，我们讨论了关于前体细胞的特异性和定向到不同 DC 亚群的协调的新证据，并强调了控制这些过程的转录因子的集合。
