多能干细胞的皮质神经发生：从简单中浮现的复杂性。
Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity.
作者信息
Anderson Stewart, Vanderhaeghen Pierre
机构信息
Children's Hospital of Philadelphia, UPenn School of Medicine, Philadelphia, PA 19104-5127, United States.
Université Libre de Bruxelles (ULB), WELBIO, Institute for Interdisciplinary Research (IRIBHM), and ULB Institute of Neuroscience (UNI), 808 Route de Lennik, B-1070 Brussels, Belgium.
出版信息
Curr Opin Neurobiol. 2014 Aug;27:151-7. doi: 10.1016/j.conb.2014.03.012. Epub 2014 Apr 18.
Abstract
The cerebral cortex contains dozens of neuronal subtypes grouped in specific layers and areas. Recent studies have revealed how embryonic and induced pluripotent stem cells (PSC) can differentiate into a wide diversity of cortical neurons in vitro, while recapitulating many of the temporal and spatial features that characterize corticogenesis. PSC-derived neurons can integrate into the brain following in vivo transplantation and display patterns of morphology and connectivity specific of cortical neurons. PSC-corticogenesis thus emerges as a robust model that provides new ways to link cortical development, evolution, and disease.
摘要
大脑皮层包含数十种神经元亚型，这些亚型按特定的层和区域分组。最近的研究揭示了胚胎干细胞和诱导多能干细胞（PSC）如何在体外分化为多种多样的皮层神经元，同时重现了许多构成皮质发生特征的时空特征。PSC衍生的神经元在体内移植后可以整合到大脑中，并表现出皮层神经元特有的形态和连接模式。因此，PSC-皮质发生成为一个强大的模型，为连接皮层发育、进化和疾病提供了新的途径。
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