多瘤病毒微小核糖核酸：开端
Polyomavirus miRNAs: the beginning.
作者信息
Imperiale Michael J
机构信息
Department of Microbiology and Immunology, University of Michigan, 1150 West Medical Center Drive, 5724 Medical Science Building II, Ann Arbor, MI 48109, United States.
出版信息
Curr Opin Virol. 2014 Aug;7:29-32. doi: 10.1016/j.coviro.2014.03.012. Epub 2014 Apr 17.
Abstract
Polyomaviruses are small, double stranded DNA viruses that replicate in the nucleus of the infected cell. Since 2005, clear evidence for miRNAs has been presented for a subset of the members of this viral family, each of which express a single miRNA. All the miRNAs share in common the ability to regulate expression of the major viral regulatory protein, large T antigen. Growing evidence suggests that the major role of the miRNA is to control viral replication. In vitro studies suggesting an immmunomodulatory role for the miRNA have not been supported by in vivo infections. Very little is known about cellular targets of the viral miRNAs, however. Thus, much remains to be learned about these interesting non-coding RNAs.
摘要
多瘤病毒是一种小型双链DNA病毒，在受感染细胞的细胞核中进行复制。自2005年以来，已明确有证据表明该病毒家族的一部分成员存在微小RNA（miRNA），每个成员都表达一种单一的miRNA。所有这些miRNA都具有调控主要病毒调节蛋白——大T抗原表达的共同能力。越来越多的证据表明，miRNA的主要作用是控制病毒复制。然而，体外研究提示miRNA具有免疫调节作用，但体内感染实验并未证实这一点。目前对病毒miRNA的细胞靶点知之甚少。因此，关于这些有趣的非编码RNA仍有许多有待了解之处。
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