Miyake Teruki, Kumagi Teru, Hirooka Masashi, Furukawa Shinya, Kawasaki Keitarou, Koizumi Mitsuhito, Todo Yasuhiko, Yamamoto Shin, Nunoi Hiroaki, Tokumoto Yoshio, Ikeda Yoshio, Abe Masanori, Kitai Kohichiro, Matsuura Bunzo, Hiasa Yoichi
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
J Gastroenterol. 2015 Feb;50(2):230-7. doi: 10.1007/s00535-014-0959-6. Epub 2014 Apr 21.
Nonalcoholic fatty liver disease (NAFLD) is a risk factor for diabetes and cardiovascular disease that could progress to nonalcoholic steatohepatitis, cirrhosis, and liver failure. We aimed to assess the relationship between NAFLD and lifestyle habits.
Using a community-based, cross-sectional design, the records of 11,094 Japanese subjects who had undergone at least 1 annual health checkup were reviewed.
Of the 6,370 subjects who qualified for enrolment, 1,346 met the diagnostic criteria for NAFLD. The prevalence rate (PR) of NAFLD increased significantly to 36.6, 41.5, and 41.1 % with no snacking, snacking less than once/day, and snacking ≥2 times/day, respectively, in men (P = 0.0495) and to 10.8, 11.7, and 15.3 %, respectively, in women (P = 0.002). In men, the NAFLD PR decreased significantly to 48.8, 36.9, and 29.9 % with no exercise, exercise consciousness, and periodical exercise, respectively (P < 0.001). In women, the NAFLD PR decreased significantly to 19.3, 13.5, 11, and 8 % with sleep durations of ≤4, 5-6, 7-8, and ≥9 h, respectively (P = 0.003). Periodical exercise was identified as an independent factor associated with NAFLD in men (odds ratio 0.707, 95 % confidence interval 0.546-0.914; P = 0.008).
Performing regular exercise was associated with a reduced risk for NAFLD in men. Men with a high risk for NAFLD can be identified using questionnaires on exercise in an outpatient setting. Disease progression and further complications may be prevented by educating high-risk NAFLD patients about the importance of exercise.
非酒精性脂肪性肝病（NAFLD）是糖尿病和心血管疾病的危险因素，可能进展为非酒精性脂肪性肝炎、肝硬化和肝衰竭。我们旨在评估NAFLD与生活习惯之间的关系。
采用基于社区的横断面设计，回顾了11094名至少进行过一次年度健康检查的日本受试者的记录。
在符合入选条件的6370名受试者中，1346名符合NAFLD的诊断标准。男性中，不吃零食、每天吃零食少于一次和每天吃零食≥2次的受试者，NAFLD患病率（PR）分别显著升至36.6%、41.5%和41.1%（P = 0.0495）；女性中，相应患病率分别为10.8%、11.7%和15.3%（P = 0.002）。男性中，不运动、有运动意识和定期运动的受试者，NAFLD PR分别显著降至48.8%、36.9%和29.9%（P < 0.001）。女性中，睡眠时间≤4小时、5 - 6小时、7 - 8小时和≥9小时的受试者，NAFLD PR分别显著降至19.3%、13.5%、11%和8%（P = 0.003）。定期运动被确定为男性中与NAFLD相关的独立因素（比值比0.707，95%置信区间0.546 - 0.914；P = 0.008）。
定期运动与男性患NAFLD风险降低相关。在门诊环境中，可通过运动问卷识别出NAFLD高风险男性。对NAFLD高风险患者进行运动重要性的教育，可能预防疾病进展和进一步并发症。
