Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto,
J Gastrointestin Liver Dis. 2019 Mar;28(1):73-81. doi: 10.15403/jgld.2014.1121.281.alc.
Previous cross-sectional studies revealed that short sleep duration has a close relationship with the presence of non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the association between sleep duration and incident NAFLD.
In this historical cohort study of 12,306 participants (5,848 men and 6,458 women), we investigated the effect of sleep duration on incident NAFLD. NAFLD was defined as having fatty liver diagnosed by abdominal ultrasonography in the participants who consumed ethanol less than 30 g/day for men and 20 g/day for women. We divided the participants into four groups according to sleep duration: >7, >6-7, >5-6, and </=5h. Cox proportional hazards models were performed to investigate the effect of sleep duration on incident NAFLD, adjusting for age, body mass index categories, alanine aminotransferase, triglycerides, high density lipoprotein-cholesterol, fasting plasma glucose, smoking status, alcohol consumption, systolic blood pressure, exercise.
During the median 6.8-year follow-up for men and the 7.0-year follow-up duration for women, 2,280 participants (1,581 men and 699 women) developed NAFLD. In Cox proportional hazards models, sleep duration of </=5 h in both men and women were revealed to be a significant risk for incident NAFLD, compared to men and women with a sleep duration of >7 h (men: hazard ratio 1.39, 95% confidence interval 1.13-1.72, p=0.002; women; 1.46, 1.05-2.04, p=0.023).
This is the first study showing that short sleep duration was a risk factor for incident NAFLD.
先前的横断面研究表明，睡眠时间短与非酒精性脂肪性肝病（NAFLD）的发生密切相关。我们旨在研究睡眠时间与NAFLD 发病的关系。
在这项针对 12306 名参与者（5848 名男性和 6458 名女性）的历史队列研究中，我们调查了睡眠时间对 NAFLD 发病的影响。NAFLD 的定义为在每天摄入乙醇少于 30 克的男性和 20 克的女性参与者中，通过腹部超声诊断为脂肪肝。我们根据睡眠时间将参与者分为四组：>7 小时、>6-7 小时、>5-6 小时和<=5 小时。采用 Cox 比例风险模型，在调整年龄、体重指数类别、丙氨酸氨基转移酶、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、吸烟状况、饮酒量、收缩压、运动等因素后，研究睡眠时间对 NAFLD 发病的影响。
在男性中位 6.8 年和女性中位 7.0 年的随访期间，2280 名参与者（1581 名男性和 699 名女性）发生了 NAFLD。在 Cox 比例风险模型中，与睡眠时间>7 小时的男性和女性相比，睡眠时间<=5 小时的男性和女性发生 NAFLD 的风险显著增加（男性：风险比 1.39，95%置信区间 1.13-1.72，p=0.002；女性：1.46，1.05-2.04，p=0.023）。
这是第一项表明睡眠时间短是 NAFLD 发病的危险因素的研究。
