Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
J Gastroenterol Hepatol. 2013 Dec;28 Suppl 4:71-8. doi: 10.1111/jgh.12251.
Non-alcoholic fatty liver disease (NAFLD) may progress to cirrhosis, liver failure, and complicated hepatocellular carcinoma. In addition, NAFLD is a risk factor for the development of other serious diseases, such as diabetes or cardiovascular disease. Therefore, the detection of early-stage NAFLD is important. Many studies have described the factors that predict the presence of NAFLD and its onset, and several markers have been identified. These markers have enabled the identification of high-risk patients and have improved routine medical practice. To prevent advanced disease, clinicians need to have simple markers that predict the onset of NAFLD so that interventions can be started at much earlier stages of disease. This review summarizes the current state of knowledge regarding independent factors, as reported in large studies, that predict the presence of NAFLD and its onset, especially markers that can be used in daily medical practice, such as physical measurements and blood tests.
非酒精性脂肪性肝病（NAFLD）可能进展为肝硬化、肝功能衰竭和复杂的肝细胞癌。此外，NAFLD 是发生其他严重疾病的一个风险因素，如糖尿病或心血管疾病。因此，早期发现 NAFLD 很重要。许多研究描述了预测 NAFLD 存在及其发病的因素，并确定了一些标志物。这些标志物使能够识别高危患者，并改善常规医疗实践。为了预防进展性疾病，临床医生需要具有简单的标志物来预测 NAFLD 的发病，以便在疾病的早期阶段就开始干预。这篇综述总结了关于预测 NAFLD 存在及其发病的独立因素的最新知识状态，特别是可用于日常医疗实践的标志物，如体格检查和血液检查。
