具有多个输出信号的生物催化级联反应——迈向具有不同置信水平的生物传感器。
A biocatalytic cascade with several output signals--towards biosensors with different levels of confidence.
作者信息
Guz Nataliia, Halámek Jan, Rusling James F, Katz Evgeny
机构信息
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, 13699-5810, USA.
出版信息
Anal Bioanal Chem. 2014 May;406(14):3365-70. doi: 10.1007/s00216-014-7789-5. Epub 2014 Apr 20.
Abstract
The biocatalytic cascade based on enzyme-catalyzed reactions activated by several biomolecular input signals and producing output signal after each reaction step was developed as an example of a logically reversible information processing system. The model system was designed to mimic the operation of concatenated AND logic gates with optically readable output signals generated at each step of the logic operation. Implications include concurrent bioanalyses and data interpretation for medical diagnostics.
摘要
基于由多个生物分子输入信号激活并在每个反应步骤后产生输出信号的酶催化反应的生物催化级联，被开发为一种逻辑可逆信息处理系统的示例。该模型系统旨在模拟级联与逻辑门的操作，在逻辑操作的每个步骤生成光学可读的输出信号。其应用包括用于医学诊断的并行生物分析和数据解读。
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