New York Neurological Consultants, New York, NY, USA.
J Pain Res. 2014 Apr 12;7:211-8. doi: 10.2147/JPR.S45321. eCollection 2014.
Goals for the management of osteoarthritis (OA) emphasize pain relief, reduction of inflammation, and improvement in functioning. Among pharmacological pain management interventions, nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently recommended as the most effective treatment option for OA. However, the use of traditional oral NSAIDs is associated with risk of serious adverse events involving the gastrointestinal, cardiovascular, and renal systems. Topical NSAIDs are an alternative with well-established tolerability and efficacy in the treatment of OA of the knee or hand. While the management of OA pain is evolving toward the more widespread use of topical NSAIDs, some OA management guidelines have yet to incorporate these agents in their recommendations. This review examines the efficacy and tolerability of topical NSAIDs, their current placement in OA management guidelines, and their potential role in enabling pain specialists to provide individualized care for their patients with OA.
骨关节炎（OA）管理的目标强调缓解疼痛、减轻炎症和改善功能。在药物治疗干预中，非甾体抗炎药（NSAIDs）常被推荐为 OA 的最有效治疗选择。然而，传统口服 NSAIDs 的使用与涉及胃肠道、心血管和肾脏系统的严重不良事件风险相关。局部 NSAIDs 是一种替代选择，在治疗膝或手部 OA 方面具有良好的耐受性和疗效。虽然 OA 疼痛管理正朝着更广泛地使用局部 NSAIDs 的方向发展，但一些 OA 管理指南尚未将这些药物纳入其建议中。本综述检查了局部 NSAIDs 的疗效和耐受性、它们在 OA 管理指南中的当前位置，以及它们在使疼痛专家能够为 OA 患者提供个性化护理方面的潜在作用。
