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原发性肛管直肠黑色素瘤

Primary anorectal melanoma.

作者信息

Khan Maliha, Bucher Nora, Elhassan Ahmed, Barbaryan Aram, Ali Alaa M, Hussain Nasir, Mirrakhimov Aibek E

机构信息

Department of Internal Medicine, Presence Saint Joseph Hospital, Chicago, Ill., USA.

出版信息

Case Rep Oncol. 2014 Mar 13;7(1):164-70. doi: 10.1159/000360814. eCollection 2014 Jan.

Abstract

Primary malignant melanoma of the anus and rectum is a rare and aggressive neoplasm that tends to invade locally and metastasize early in the course of the disease. It is often misdiagnosed as hemorrhoids or as one of the other benign anorectal conditions and is thus linked to an overall poor prognosis and a 5-year survival rate of less than 20%. Optimal treatment is still controversial, and current evidence does not show any preferential survival benefit from abdominoperineal resection over wide local excision. Chemotherapy or radiotherapy may be used for advanced disease. We report a 71-year-old female presenting with painful bowel movements and blood in stools. She was eventually found to have a mass arising from the anorectal junction with regional lymph node involvement. The patient underwent an abdominoperineal resection and is currently scheduled for chemotherapy.

摘要

肛管直肠原发性恶性黑色素瘤是一种罕见且侵袭性强的肿瘤,在疾病过程中往往易于局部浸润并早期发生转移。它常被误诊为痔疮或其他良性肛肠疾病,因此总体预后较差,5年生存率低于20%。最佳治疗方案仍存在争议,目前的证据并未显示腹会阴联合切除术比广泛局部切除术有任何更优的生存获益。化疗或放疗可用于晚期疾病。我们报告一例71岁女性,表现为排便疼痛和便血。最终发现她在肛管直肠交界处有肿物并伴有区域淋巴结受累。该患者接受了腹会阴联合切除术,目前计划进行化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc8/3985785/d3eec7e25a20/cro-0007-0164-g01.jpg

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