Department of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.
Department of Emergency, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China.
J Geriatr Cardiol. 2014 Mar;11(1):57-62. doi: 10.3969/j.issn.1671-5411.2014.01.003.
To investigate the relationship between serum free fatty acids (FFAs) levels and the severity of coronary artery lesions in elderly patients with coronary heart disease (CAD).
A total of 172 elderly patients who underwent coronary angiography were divided into CAD group (n = 128) and non-CAD group (n = 44) according to the results of coronary angiography. Serum FFAs and lipid levels were measured and the Gensini score were calculated.
No matter the differences between age, gender and the usage of statins or not, there was no statistical significance in FFAs levels (P > 0.05). In terms of the Gensini score, it was higher in patients aged 70-79 years than in patients 60-69 years old [15.00 (5.00, 34.00) vs. 10.00 (2.00, 24.00), P < 0.05], higher in men than women [14.00 (4.00, 34.00) vs. 7.00 (2.50, 19.75), P < 0.05], and higher in patients on statins [13.50 (4.25, 33.50) vs. 6.50 (2.00, 18.00), P < 0.05]. The serum FFAs levels [449.50 (299.00, 624.75) mEq/L vs. 388.00 (258.50, 495.25) mEq/L, P < 0.05] and Gensini score [17.50 (8.00, 41.75) vs. 1.00 (0, 5.00), P < 0.05] were higher in the CAD group than in the non-CAD group. In the CAD group, there was no statistical significance in FFAs levels among patients with different numbers of diseased coronary vessels (P > 0.05). Furthermore, the FFAs levels were positively correlated with the Gensini score (r = 0.394, P = 0.005). Regression analysis showed that the FFAs levels were related to the Gensini score independently after adjusting for the other risk factors.
The serum FFAs levels were associated with the Gensini score in elderly patients with CAD. It might indicate FFAs as a biomarker predicting the severity of coronary artery lesions.
探讨老年冠心病（CAD）患者血清游离脂肪酸（FFAs）水平与冠状动脉病变严重程度的关系。
根据冠状动脉造影结果，将 172 例行冠状动脉造影的老年患者分为 CAD 组（n=128）和非 CAD 组（n=44）。检测血清 FFAs 和血脂水平，并计算 Gensini 评分。
无论年龄、性别、是否使用他汀类药物的差异如何，FFAs 水平均无统计学意义（P＞0.05）。在 Gensini 评分方面，70-79 岁患者高于 60-69 岁患者[15.00（5.00，34.00）比 10.00（2.00，24.00），P＜0.05]，男性高于女性[14.00（4.00，34.00）比 7.00（2.50，19.75），P＜0.05]，使用他汀类药物的患者高于未使用的患者[13.50（4.25，33.50）比 6.50（2.00，18.00），P＜0.05]。CAD 组血清 FFAs 水平[449.50（299.00，624.75）mEq/L 比 388.00（258.50，495.25）mEq/L，P＜0.05]和 Gensini 评分[17.50（8.00，41.75）比 1.00（0，5.00），P＜0.05]均高于非 CAD 组。在 CAD 组中，不同病变冠状动脉数量的患者之间的 FFAs 水平无统计学意义（P＞0.05）。此外，FFAs 水平与 Gensini 评分呈正相关（r=0.394，P=0.005）。回归分析显示，调整其他危险因素后，FFAs 水平与 Gensini 评分独立相关。
老年 CAD 患者血清 FFAs 水平与 Gensini 评分相关，提示 FFAs 可能是预测冠状动脉病变严重程度的生物标志物。
