Zhang Yanan, Qi Xi, Wang Siming, Zhang Wenduo, Yang Ruiyue, Wang Xinyue, Chen Wenxiang, Ji Fusui, Dong Jun, Yu Xue
The Affiliated Hospital of Qingdao University, Qing Dao, Shan Dong, China.
Beijing Hospital, Beijing, China.
PeerJ. 2024 Mar 5;12:e17012. doi: 10.7717/peerj.17012. eCollection 2024.
The purpose of this study was to investigate the relationship between serum immunoglobulin M (IgM) and the severity of coronary artery disease in Chinese patients who underwent coronary angiography.
A total of 2,045 patients who underwent coronary angiography (CAG) from March 2017 to March 2020 at Beijing Hospital were included in this study. Serum IgM concentration and biochemical indicators were measured before coronary angiography (CAG). The triquartile IgM levels at baseline in the population were analysed. Spearman rank correlation was used to analyse the association between IgM and traditional risk factors for coronary artery disease (CAD). CAD patients were divided into subgroups by affected area, number of affected vessels, and Gensini score to analyse the relationship between IgM and CAD severity. Multivariable logistic regression analysis was used to evaluate the association between IgM and CAD severity.
Serum IgM levels were significantly lower in the CAD group (63.5 mg/dL) than in the non-coronary artery disease (NCAD) group (72.3 mg/dL) ( < 0.001). Serum IgM levels were significantly associated with sex. Serum IgM levels were positively correlated with traditional CAD risk factors such as TG, TC and LDL-C ( < 0.05), and negatively associated with the number of obstructed vessels, the number of affected areas, and Gensini scores. After adjusting for age, sex, smoking status, hypertension, dyslipidaemia, diabetes, stroke, and statin use history, a high IgM level was independently negatively associated with the severity of CAD expressed by the Gensini score.
We determined that serum IgM was independently negatively associated with the severity of CAD diagnosed by angiography in Chinese adults.
本研究旨在探讨接受冠状动脉造影的中国患者血清免疫球蛋白M（IgM）与冠状动脉疾病严重程度之间的关系。
本研究纳入了2017年3月至2020年3月在北京医院接受冠状动脉造影（CAG）的2045例患者。在冠状动脉造影（CAG）前测量血清IgM浓度和生化指标。分析人群基线时的四分位数IgM水平。采用Spearman等级相关性分析IgM与冠状动脉疾病（CAD）传统危险因素之间的关联。CAD患者按病变部位、病变血管数量和Gensini评分进行分组，以分析IgM与CAD严重程度之间的关系。采用多变量逻辑回归分析评估IgM与CAD严重程度之间的关联。
CAD组血清IgM水平（63.5mg/dL）显著低于非冠状动脉疾病（NCAD）组（72.3mg/dL）（<0.001）。血清IgM水平与性别显著相关。血清IgM水平与TG、TC和LDL-C等CAD传统危险因素呈正相关（<0.05），与阻塞血管数量、病变部位数量和Gensini评分呈负相关。在调整年龄、性别、吸烟状况、高血压、血脂异常、糖尿病、中风和他汀类药物使用史后，高IgM水平与以Gensini评分表示的CAD严重程度独立呈负相关。
我们确定血清IgM与中国成年人经血管造影诊断的CAD严重程度独立呈负相关。
