DNA甲基化作为癌症的早期诊断标志物（综述）。
DNA methylation as an early diagnostic marker of cancer (Review).
作者信息
Dong Yuanyuan, Zhao Haiyang, Li Haiyan, Li Xiaokun, Yang Shulin
机构信息
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P.R. China ; Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P.R. China.
出版信息
Biomed Rep. 2014 May;2(3):326-330. doi: 10.3892/br.2014.237. Epub 2014 Feb 14.
DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with the mechanisms underlying cell growth, differentiation and transformation in eukaryotes. Global changes in the epigenetic landscape are considered to be a hallmark of cancer. The initiation and progression of cancer are mediated through epigenetic modifications along with genetic alterations. Aberrant methylation of promoter regions is an epigenetic abnormality of the human genome that is highly characteristic of cancer. In this review, we aimed to summarize our current understanding of the alterations in the epigenetic landscape and investigate the potential use of DNA and RNA methylation in effective molecular treatment strategies.
DNA甲基化是一种重要的表观遗传机制，与真核生物中细胞生长、分化和转化的机制密切相关。表观遗传格局的全局变化被认为是癌症的一个标志。癌症的发生和发展是通过表观遗传修饰以及基因改变介导的。启动子区域的异常甲基化是人类基因组的一种表观遗传异常，是癌症的高度特征。在本综述中，我们旨在总结我们目前对表观遗传格局改变的理解，并研究DNA和RNA甲基化在有效的分子治疗策略中的潜在用途。
Zotero 插件