Bevelacqua Resources , USA.
PeerJ. 2014 Apr 1;2:e320. doi: 10.7717/peerj.320. eCollection 2014.
The feasibility of disrupting a tumor's vascular structure with various radiation types and radionuclides is investigated. Calculated absorbed dose profiles for photons and (4)He ions suggest that low-energy beta-gamma and alpha emitting radionuclides can deposit sufficient absorbed dose to disrupt a tumor's vascular structure while minimizing the dose outside the blood vessel. Candidate radionuclides uniformly distributed in microspheres are theoretically investigated with respect to their vascular disruption potential and to offer an alternative to (90)Y microsphere therapy. Requisite activities of candidate low-energy beta-gamma and alpha emitting radionuclides to facilitate vascular disruption are calculated.
研究了用各种辐射类型和放射性核素破坏肿瘤血管结构的可行性。光子和(4)He 离子的计算吸收剂量分布表明，低能β-γ和α发射放射性核素可以沉积足够的吸收剂量来破坏肿瘤的血管结构，同时使血管外的剂量最小化。理论上研究了均匀分布在微球中的候选放射性核素，以评估其血管破坏潜力，并为(90)Y 微球治疗提供替代方案。计算了促进血管破坏所需的候选低能β-γ和α发射放射性核素的必要活度。
