a Lung Cancer Branch , Research Institute, National Cancer Center , Goyang , Gyeonggi-do , South Korea.
J Toxicol Environ Health B Crit Rev. 2014;17(3):127-74. doi: 10.1080/10937404.2014.882194.
Endocrine-disrupting chemicals (EDC), including phthalates, bisphenol A (BPA), phytoestrogens such as genistein and daidzein, dichlorodiphenyltrichloroethane (DDT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are associated with a variety of adverse health effects in organisms or progeny by altering the endocrine system. Environmental estrogens, including BPA, phthalates, and phytoestrogens, are the most extensively studied and are considered to mimic the actions of endogenous estrogen, 17β-estradiol (E2). Diverse modes of action of estrogen and estrogen receptors (ERα and ERβ) have been described, but the mode of action of estrogenic EDC is postulated to be more complex and needs to be more clearly elucidated. This review examines the adverse effects of estrogenic EDC on male or female reproductive systems and molecular mechanisms underlying EDC effects that modulate ER-mediated signaling. Mechanisms of action for estrogenic EDC may involve both ER-dependent and ER-independent pathways. Recent findings from systems toxicology of examining estrogenic EDC are also discussed.
内分泌干扰化学物质（EDC），包括邻苯二甲酸酯、双酚 A（BPA）、植物雌激素如染料木黄酮和大豆黄酮、二氯二苯三氯乙烷（DDT）和 2,3,7,8-四氯二苯并对二恶英（TCDD），通过改变内分泌系统，与生物体或后代的各种不良健康影响有关。环境雌激素，包括 BPA、邻苯二甲酸酯和植物雌激素，是研究最广泛的，被认为模拟内源性雌激素 17β-雌二醇（E2）的作用。已经描述了雌激素和雌激素受体（ERα 和 ERβ）的多种作用模式，但假定雌激素性 EDC 的作用模式更为复杂，需要更清楚地阐明。本文综述了雌激素性 EDC 对男性或女性生殖系统的不良影响，以及调节 ER 介导的信号转导的 EDC 作用的分子机制。雌激素性 EDC 的作用机制可能既涉及 ER 依赖性途径，也涉及 ER 非依赖性途径。还讨论了最近从雌激素性 EDC 的系统毒理学检查中获得的发现。
