尿 8-羟基-2'-脱氧鸟苷（8-oxodG）水平可预测尿路感染的幼儿急性肾损伤。
Urinary 8-hydroxy-2'-deoxyguanosine (8-oxodG) level can predict acute renal damage in young children with urinary tract infection.
机构信息
Departments of Pediatrics .
出版信息
Biomarkers. 2014 Jun;19(4):326-31. doi: 10.3109/1354750X.2014.910552. Epub 2014 Apr 21.
BACKGROUND
There are no good biomarkers to predict renal parenchymal involvement in children with urinary tract infection (UTI).
METHODS
Children (N = 73) younger than 5 years with UTI were enrolled. Urinary levels of 8-hydroxy-2'-deoxyguanosine (8-oxodG) and total antioxidant capacity (TAC) were checked as markers of oxidative stress and antioxidant capacity, respectively. Tc99m-dimercaptosuccinic acid (DMSA) renal scintigraphy was used to find evidence of renal involvement.
RESULTS
Patients with positive DMSA findings had higher levels of urinary 8-oxodG (p = 0.003) and higher urinary TAC (p = 0.001) than patients with normal DMSA findings.
CONCLUSIONS
High level of urinary 8-oxodG may be a risk factor of severe renal damage.
背景
目前尚无良好的生物标志物可用于预测尿路感染（UTI）患儿的肾实质受累情况。
方法
本研究纳入了 73 名年龄小于 5 岁的 UTI 患儿。分别检测尿液中 8-羟基-2'-脱氧鸟苷（8-oxodG）和总抗氧化能力（TAC）的水平，以作为氧化应激和抗氧化能力的标志物。采用 Tc99m-二巯丁二酸（DMSA）肾闪烁扫描来寻找肾脏受累的证据。
结果
DMSA 检查阳性的患者尿液中的 8-oxodG 水平更高（p=0.003），尿液中的 TAC 水平也更高（p=0.001）。
结论
高水平的尿液 8-oxodG 可能是严重肾损伤的危险因素。
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