抗上皮膜抗原（EMA）、AGF 4:48及荆豆凝集素-1（UEA-1）与人类卵巢癌的结合：组织学和临床相关性

Binding of anti-EMA, AGF 4:48 and the lectin UEA-1 to human ovarian carcinomas: histological and clinical correlations.

作者信息

Bradgate M G, Redman C W, Rollason T P, Williams A, Byrne P, Kelly K

机构信息

Department of Histology, Birmingham Maternity Hospital.

出版信息

Br J Obstet Gynaecol. 1989 Jul;96(7):854-60. doi: 10.1111/j.1471-0528.1989.tb03328.x.

DOI:10.1111/j.1471-0528.1989.tb03328.x

PMID:2475159

Abstract

The staining reactions of the monoclonal antibodies anti-EMA, AGF 4:48 and the lectin UEA-1 from Ulex europaeus were investigated in formalin-fixed, paraffin-embedded sections of 36 primary ovarian carcinomas. The staining patterns were graded and related to tumour type, differentiation, FIGO stage and patient survival. Both antibodies and UEA-1 showed variations in their staining between and within tumours. The staining of mucinous tumours using anti-EMA was significantly less than in non-mucinous tumours. No other significant associations were found between staining grade and the different variables under study. The variations in staining were not demonstrated to have any prognostic significance.

摘要

在36例原发性卵巢癌的福尔马林固定、石蜡包埋切片中，研究了抗上皮膜抗原（EMA）单克隆抗体、AGF 4:48和来自欧洲荆豆的凝集素荆豆凝集素-1（UEA-1）的染色反应。对染色模式进行分级，并与肿瘤类型、分化程度、国际妇产科联盟（FIGO）分期和患者生存率相关联。两种抗体和UEA-1在肿瘤之间和肿瘤内部的染色都存在差异。使用抗EMA对黏液性肿瘤的染色明显少于非黏液性肿瘤。在染色分级与所研究的不同变量之间未发现其他显著关联。染色的差异未被证明具有任何预后意义。