Böckle Barbara C, Jara David, Nindl Werner, Aberer Werner, Sepp Norbert T
Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria.
Dermatology. 2014;228(4):289-93. doi: 10.1159/000358427. Epub 2014 Apr 15.
The treatment of chronic inflammatory skin disease is associated with the use of topical corticosteroids. Their efficacy, tolerability and adverse effects depend on several factors, specifically potency, type of preparation, extemporaneous dilutions, quantity used, magnitude of the treated body surface, frequency of application, location, patient age, method of application and condition of the skin barrier. We report on two men suffering from chronic inflammatory skin disease, who presented with fatigue and cushingoid appearance after prolonged self-application of potent corticosteroids. Impairment of the skin barrier due to their underlying skin disease, frequent self-application of topical steroids and repeated application of the entire body led to extensive absorption of these substances, eventually culminating in the suppression of the pituitary-hypothalamic-adrenal axis. In conclusion, topical corticosteroids are effective and well-established therapeutic modalities. However, inappropriate use of topical corticosteroids can cause side effects.
慢性炎症性皮肤病的治疗与局部使用皮质类固醇有关。它们的疗效、耐受性和不良反应取决于几个因素，特别是效力、制剂类型、临时稀释度、使用量、治疗的体表面积大小、应用频率、部位、患者年龄、应用方法和皮肤屏障状况。我们报告了两名患有慢性炎症性皮肤病的男性，他们在长期自行使用强效皮质类固醇后出现疲劳和库欣样外观。由于其潜在的皮肤疾病导致皮肤屏障受损，频繁自行使用局部类固醇以及全身反复涂抹，导致这些物质大量吸收，最终导致垂体 - 下丘脑 - 肾上腺轴受到抑制。总之，局部皮质类固醇是有效且成熟的治疗方式。然而，局部皮质类固醇使用不当会引起副作用。
