Eder H, Rosslenbroich B, Failing K
Institut für Veterinär-Physiologie, Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
Blut. 1989 Aug;59(2):184-7. doi: 10.1007/BF00320065.
The effect of human recombinant erythropoietin (rEPO) on the reticulocyte count and the reticulocyte maturation distribution in rats was measured with an automatic reticulocyte analysis system (AURAS). The strongest reaction was found on the third day after a single application of rEPO with respect to reticulocyte count, maturation distribution, and the count of immature reticulocytes. At this time these parameters show a distinct dose dependency. The results indicate a possible basis for a simple rEPO bioassay using normocytemic rats.
采用自动网织红细胞分析系统（AURAS）测定了人重组促红细胞生成素（rEPO）对大鼠网织红细胞计数及网织红细胞成熟分布的影响。单次应用rEPO后，在第三天观察到网织红细胞计数、成熟分布及未成熟网织红细胞计数方面的最强反应。此时，这些参数呈现出明显的剂量依赖性。结果表明，使用正常红细胞性大鼠进行简单的rEPO生物测定可能有依据。
