Qin Yan, Cao Ying, Gao Fang, Luo Xiangrong, Li Jimin, Fu Xiajun, Xue Yaoming
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2014 Apr;34(4):560-2.
To assess the predictive value of Neuropad test on occurrence of diabetic foot ulceration (DFU) among type 2 diabetic patients.
We divided 725 cases of type 2 diabetic patients into the high-risk and the non-high-risk groups of DFU based on the results of vibration perception thresholds(VPT) examination, which was widely used as a criteria for predicting DFU. Receiver operating characteristic (ROC) analysis was used to compare the effectiveness of Neuropad with 10 g Semmes-Weinstein monofilament (10 g SWMF) testing in predicting the risk of DFU.
Among 725 patients of type 2 diabetes, 6.1% were at a high risk of DFU. Compared to non-high-risk group, patients in high-risk group had older age, longer diabetes duration, higher values of complete colour change time (CCC time) of Neuropad and higher abnormal rate of 10 g SWMF (P<0.01). CCC time of Neuropad was shown to be better in predicting the risk of DFU than 10 g SWMF, and the area under the ROC curve was about 0.8, and the best cut-off value was 22.25 min.
Neuropad is an effective means for predicting of the risk of DFU, and can be used to prevent diabetic foot ulceration.
评估Neuropad测试对2型糖尿病患者糖尿病足溃疡（DFU）发生的预测价值。
我们根据振动觉阈值（VPT）检查结果，将725例2型糖尿病患者分为DFU高危组和非高危组，VPT检查被广泛用作预测DFU的标准。采用受试者工作特征（ROC）分析比较Neuropad与10g Semmes-Weinstein单丝（10g SWMF）测试在预测DFU风险方面的有效性。
在725例2型糖尿病患者中，6.1%处于DFU高危状态。与非高危组相比，高危组患者年龄更大、糖尿病病程更长、Neuropad的完全变色时间（CCC时间）值更高，10g SWMF异常率更高（P<0.01）。结果显示，Neuropad的CCC时间在预测DFU风险方面优于10g SWMF，ROC曲线下面积约为0.8，最佳截断值为22.25分钟。
Neuropad是预测DFU风险的有效手段，可用于预防糖尿病足溃疡。
