Sun Yi, Tabata Keiichi, Matsubara Hideki, Kitanaka Susumu, Suzuki Takashi, Yasukawa Ken
College of Pharmacy, Nihon University, Chiba, Japan.
Planta Med. 2008 Mar;74(4):427-31. doi: 10.1055/s-2008-1034345.
Bioassay-guided fractionation of the cytotoxic MeOH extract from the rhizomes of Alpinia officinarum Hance led to the isolation of two new diarylheptanoids named alpinoid D (1) and E (2), together with fifteen known diarylheptanoids (3 - 17). The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic data and chemical evidence. The cytotoxic activity of the isolated diarylheptanoids was evaluated against the IMR-32 human neuroblastoma cell line. Among the tested compounds, 11, 12 and 14 exhibited the most potent activities with IC (50) values of 0.83, 0.23 and 0.11 microM, respectively.
采用生物活性追踪法对高良姜根茎的细胞毒性甲醇提取物进行分离，从中分离得到两个新的二芳基庚烷类化合物，分别命名为高良姜素D（1）和E（2），以及15个已知的二芳基庚烷类化合物（3 - 17）。通过光谱数据和化学证据对化合物1和2的结构进行了鉴定。对分离得到的二芳基庚烷类化合物针对IMR - 32人神经母细胞瘤细胞系的细胞毒性活性进行了评估。在所测试的化合物中，11、12和14表现出最强的活性，IC（50）值分别为0.83、0.23和0.11微摩尔。
