高良姜根茎中的二芳基庚烷类化合物及其抗癌活性。
Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity.
作者信息
An Ning, Zou Zhong-mei, Tian Ze, Luo Xiu-zhen, Yang Shi-lin, Xu Li-zhen
机构信息
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.
出版信息
Fitoterapia. 2008 Jan;79(1):27-31. doi: 10.1016/j.fitote.2007.07.001. Epub 2007 Aug 9.
Two new diarylheptanoids (1, 2), together with two known analogs (3, 4), were isolated from the rhizomes of Alpinia officinarum. The new compounds were elucidated to be (5S)-5-hydroxy-7-(3, 4-dihydroxyphenyl)-1-phenyl-3-heptanone (1) and (5R)-5-hydroxy-7-(3-methoxy-4, 5-dihydroxyphenyl)-1-phenyl-3-heptanone (2) based on their spectral analysis. Compound 4 showed moderate cytotoxicity against human tumor cell lines, HepG2, MCF-7 and SF-268, while no significant effect were found for compounds 1-3.
从高良姜根茎中分离出两种新的二芳基庚烷类化合物（1、2）以及两种已知类似物（3、4）。通过光谱分析确定新化合物分别为(5S)-5-羟基-7-(3,4-二羟基苯基)-1-苯基-3-庚酮（1）和(5R)-5-羟基-7-(3-甲氧基-4,5-二羟基苯基)-1-苯基-3-庚酮（2）。化合物4对人肿瘤细胞系HepG2、MCF-7和SF-268显示出中等细胞毒性，而化合物1-3未发现显著作用。
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