艾氏内酯A - F，源自植物内生真菌突脐孢属（Exserohilum sp.）的新型异香豆素衍生物

Exserolides A-F, new isocoumarin derivatives from the plant endophytic fungus Exserohilum sp.

作者信息

Li Ruxin, Chen Shenxi, Niu Shubin, Guo Liangdong, Yin Jun, Che Yongsheng

机构信息

Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; State Key Laboratory of Antitoxic Drugs & Toxicology, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China.

State Key Laboratory of Antitoxic Drugs & Toxicology, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China.

出版信息

Fitoterapia. 2014 Jul;96:88-94. doi: 10.1016/j.fitote.2014.04.013. Epub 2014 Apr 18.

DOI:10.1016/j.fitote.2014.04.013

PMID:24752143

Abstract

Six new isocoumarin derivatives, exserolides A-F (1-6), were isolated from solid cultures of the plant endophytic fungus Exserohilum sp., together with four known metabolites (7-10). The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configuration of the C-3 methine carbon in 1-5 was deduced via the circular dichroism data, whereas that of the 1,3-diol moiety in 6 was assigned from the (1)H NMR data of its (R)- and (S)-MTPA diesters. Compounds 3 and 9 showed antifungal activity against the plant pathogen Fusarium oxysporum, whereas 6 displayed significant inhibitory effects against a small panel of bacteria.

摘要

从植物内生真菌凸脐蠕孢菌（Exserohilum sp.）的固体培养物中分离出6个新的异香豆素衍生物，即外盘菌素A - F（1 - 6），以及4个已知的代谢产物（7 - 10）。1 - 6的结构主要通过核磁共振实验得以阐明。1 - 5中C - 3次甲基碳的绝对构型通过圆二色光谱数据推导得出，而6中1,3 - 二醇部分的绝对构型则根据其（R） - 和（S） - MTPA二酯的氢核磁共振数据确定。化合物3和9对植物病原菌尖孢镰刀菌显示出抗真菌活性，而6对一小部分细菌表现出显著的抑制作用。