来自赖氏青霉的含聚酮化合物的吡喃环。
Pyran Rings Containing Polyketides from Penicillium raistrickii.
作者信息
Ma Li-Ying, Liu De-Sheng, Li De-Guo, Huang Yu-Ling, Kang Hui-Hui, Wang Chun-Hua, Liu Wei-Zhong
机构信息
College of Pharmacy, Binzhou Medical College, Yantai 264003, China.
The Hospital of Luzhong Mining Co., Ltd., Laiwu 271113, China.
出版信息
Mar Drugs. 2016 Dec 23;15(1):2. doi: 10.3390/md15010002.
Five new pyran rings containing polyketides, penicipyrans A-E (-), together with the known pestapyrone A (), were isolated from the saline soil-derived . Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds and were established by the modified Mosher's method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (, ), three isocoumarins (, , ), and one dihydropyran derivative (). Among them, Compound exhibited cytotoxicity against HL-60 and K562 cell lines with IC values of 4.4 and 8.5 μM, respectively.
从盐渍土来源的[具体物质未提及]中分离出了五个含有聚酮化合物的新吡喃环，即青霉吡喃A - E（-），以及已知的害虫吡喃酮A（）。通过对核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）数据的解析确定了它们的结构。化合物[具体化合物未提及]和[具体化合物未提及]的绝对构型分别通过改良的莫舍尔方法和单晶X射线衍射分析确定。这些化合物具有高度的结构多样性，包括两个α - 吡喃酮（[具体化合物未提及]，[具体化合物未提及]）、三个异香豆素（[具体化合物未提及]，[具体化合物未提及]，[具体化合物未提及]）和一个二氢吡喃衍生物（[具体化合物未提及]）。其中，化合物[具体化合物未提及]对HL - 60和K562细胞系表现出细胞毒性，IC值分别为4.4和8.5 μM。
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