Departments of Medicine Western University, London, Ontario, Canada.
Department of Pathology, Western University, London, Ontario, Canada.
Ann Hepatol. 2014 May-Jun;13(3):353-6.
In non-alcoholic fatty liver disease (NALFD), it has often been assumed that an elevation in serum ferritin is likely related to inflammation rather than iron overload.
Patients referred with NAFLD were entered into a clinical study of phlebotomy therapy. A liver biopsy with liver iron concentration was done at entry and 6 months after phlebotomy (n = 56) until the patient had a low serum ferritin or developed anemia. Serum ferritin was compared to liver iron concentration, ESR, CRP, BMI and grade of inflammation on liver biopsy.
Iron removed by phlebotomy in NAFLD correlated with the decrease in serum ferritin (r = 0.57, p = 0.0014) and liver iron concentration (r = 0.57, p = 0.0013). There was no significant correlations between serum ferritin and ESR, CRP or grade of liver inflammation.
Serum ferritin is related to liver iron storage in NAFLD and decreasing body iron stores by phlebotomy is reflected by an appropriate decrease in serum ferritin. Inflammation is not the cause of the elevated serum ferritin in fatty liver disease.
在非酒精性脂肪性肝病（NALFD）中，通常认为血清铁蛋白升高可能与炎症有关，而不是铁过载。
将患有 NALFD 的患者纳入放血疗法的临床研究中。在入组时和放血后 6 个月（n = 56）进行肝活检和肝铁浓度检查，直到患者的血清铁蛋白水平降低或出现贫血。将血清铁蛋白与肝铁浓度、ESR、CRP、BMI 和肝活检炎症程度进行比较。
在 NALFD 中通过放血去除的铁与血清铁蛋白（r = 0.57，p = 0.0014）和肝铁浓度（r = 0.57，p = 0.0013）的降低相关。血清铁蛋白与 ESR、CRP 或肝炎症程度之间无显著相关性。
血清铁蛋白与 NALFD 中的肝铁储存有关，通过放血去除体内铁储存会导致血清铁蛋白的适当降低。炎症不是脂肪性肝病中血清铁蛋白升高的原因。
