高铁蛋白血症应如何进行检查和处理？

How should hyperferritinaemia be investigated and managed?

作者信息

Ong Sim Y, Nicoll Amanda J, Delatycki Martin B

机构信息

Bruce Lefroy Centre, Murdoch Childrens Research Institute, Flemington Road, Parkville, Victoria 3052, Australia; The University of Melbourne, Parkville, Victoria 3010, Australia; Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia.

The University of Melbourne, Parkville, Victoria 3010, Australia; Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia; Department of Gastroenterology, Eastern Health, Arnold Street, Box Hill, Victoria 3128, Australia; Monash University, Clayton, Victoria 3800, Australia.

出版信息

Eur J Intern Med. 2016 Sep;33:21-7. doi: 10.1016/j.ejim.2016.05.014. Epub 2016 Jun 23.

DOI:10.1016/j.ejim.2016.05.014

PMID:27346296

Abstract

Hyperferritinaemia is commonly found in clinical practice. In assessing the cause of hyperferritinaemia, it is important to identify if there is true iron overload or not as hyperferritinaemia may be seen in other conditions such as excess alcohol intake, inflammation and non-alcoholic fatty liver disease. Assessment of whether the serum ferritin level is elevated or not should take into account body mass index, gender and age. This review article provides an overview of the different causes of hyperferritinaemia, differentiating those due to iron overload from those not due to iron overload, and provides an algorithm for clinicians to use in clinical practice to carry out appropriate investigations and management.

摘要

高铁蛋白血症在临床实践中很常见。在评估高铁蛋白血症的病因时，确定是否存在真正的铁过载非常重要，因为在其他情况如过量饮酒、炎症和非酒精性脂肪性肝病中也可能出现高铁蛋白血症。评估血清铁蛋白水平是否升高应考虑体重指数、性别和年龄。这篇综述文章概述了高铁蛋白血症的不同病因，区分了由铁过载引起的病因和非铁过载引起的病因，并为临床医生提供了一种算法，以便在临床实践中进行适当的检查和管理。