Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore) zhaoyu.science.nus.edu.sg.
Angew Chem Int Ed Engl. 2014 May 19;53(21):5435-9. doi: 10.1002/anie.201402788. Epub 2014 Apr 22.
Presented herein is a new complexity-generating method in which both functionalities of α-imino esters undergo stereoselective cyclization with isocyanoacetates to produce directly linked oxazole-imidazolines, which can be transformed into highly functionalized α,β-diamino esters and imidazolinium salts in high diastereo- and enantiopurity.
本文提出了一种新的复杂性生成方法，其中α-亚氨基酯的两种官能团通过立体选择性环化与异氰基乙酸酯反应，直接生成连氧唑-咪唑啉，这些产物可以进一步转化为高非对映和对映体纯度的高度官能化的α,β-二氨基酯和咪唑啉盐。
