Assadpour Piranfar Mohammad
Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Int Cardiovasc Res J. 2014 Jan;8(1):6-8. Epub 2014 Jan 1.
Considering the increasing incidence of coronary artery stenosis as well as its related complications, the importance of its etiology, and inconsistent reports, we aimed to determine the relationship between High-sensitivity C-reactive protein (hsCRP) serum levels and severity of coronary atherosclerosis.
This cross-sectional study was conducted on the patients who referred to Taleghani Hospital, Tehran, Iran and met the inclusion criteria in 2011. Regarding the severity of the disease, the angiographic findings were categorized to mild (< 10), moderate (10 - 50), and severe (> 50) using the Gensini score classification. 1 mL blood sample was taken from each patient and transferred to the laboratory after clotting. After centrifugation, the serum hsCRP level was measured and classified in 3 levels of 1, 1 to 3, and more than 3 mg / L. The relationship between hsCRP serum levels and the severity of coronary atherosclerosis was analyzed using Chi-square test (N = 85, P value < 0.010).
This study was performed on 85 patients with the mean age of 55.7 ± 7.06 years. Besides, 64.7% of the participants were male. According to the results, 34.1%, 37.7%, and 28.2% of the patients experienced mild, moderate, and severe disease intensity, respectively. Moreover, the serum hsCRP levels were < 1, between1 and 3, and > 3 mg / L in 28.2%, 27.1%, and 44.7% of the patients, respectively. The hsCRP serum levels were significantly higher in the patients with moderate and severe artery stenosis compared to those with mild stenosis (P < 0.010).
The hsCRP serum levels were significantly related to the severity of coronary atherosclerosis.
鉴于冠状动脉狭窄的发病率及其相关并发症不断增加，其病因的重要性以及报告结果不一致，我们旨在确定高敏C反应蛋白（hsCRP）血清水平与冠状动脉粥样硬化严重程度之间的关系。
这项横断面研究于2011年对转诊至伊朗德黑兰塔莱加尼医院且符合纳入标准的患者进行。根据疾病严重程度，使用Gensini评分分类将血管造影结果分为轻度（<10）、中度（10 - 50）和重度（>50）。从每位患者采集1 mL血样，凝血后送至实验室。离心后，测量血清hsCRP水平并分为1 mg/L以下、1至3 mg/L和高于3 mg/L三个水平。使用卡方检验分析hsCRP血清水平与冠状动脉粥样硬化严重程度之间的关系（N = 85，P值<0.010）。
本研究共纳入85例患者，平均年龄为55.7±7.06岁。此外，64.7%的参与者为男性。结果显示，分别有34.1%、37.7%和28.2%的患者病情为轻度、中度和重度。此外，分别有28.2%、27.1%和44.7%的患者血清hsCRP水平<1 mg/L、介于1至3 mg/L之间和>3 mg/L。与轻度狭窄患者相比，中度和重度动脉狭窄患者的hsCRP血清水平显著更高（P<0.010）。
hsCRP血清水平与冠状动脉粥样硬化的严重程度显著相关。
