Luo Jin-guang
Cardiology of Anyang People's Hospital in Henan Province, Anyang, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Aug;26(8):789-91.
To study the relationship between serum inflammation factors interleukin-8 (IL-8), high-sensitivity C-reaction protein, tumor necrosis factor-α and coronary lesions in coronary heart disease (CHD) patients,
One hundred and six CHD patients were enrolled, 100 healthy subjects served as control group. The levels of serum IL-8, hsCRP (by) and TNF-α were determined. Coronary lesions were calculated by Gensini method.
The levels of Serum IL-8, hsCRP and TNF-α in CHD group were significantly higher than those in control group were significantly higher than those in control group (P < 0.05), and serum IL-8, hsCRP and TNF-α in CHD group increased gradually with the increase of Gensini score (P < 0.05). Pearson correlation analysis showed that Gensini score was positively correlated to IL-8 (P < 0.05), hsCRP (P < 0.05) and TNF-α (P < 0.05) in CHD group.
Severity of coronary lesions in CHD patients may be related to the levels of serum IL-8, hsCRP and TNF-α.
研究冠心病（CHD）患者血清炎症因子白细胞介素-8（IL-8）、高敏C反应蛋白、肿瘤坏死因子-α与冠状动脉病变之间的关系。
纳入106例冠心病患者，100例健康受试者作为对照组。测定血清IL-8、hsCRP及TNF-α水平。采用Gensini法计算冠状动脉病变程度。
冠心病组血清IL-8、hsCRP及TNF-α水平显著高于对照组（P<0.05），且冠心病组血清IL-8、hsCRP及TNF-α水平随Gensini评分升高而逐渐升高（P<0.05）。Pearson相关性分析显示，冠心病组Gensini评分与IL-8（P<0.05）、hsCRP（P<0.05）及TNF-α（P<0.05）呈正相关。
冠心病患者冠状动脉病变严重程度可能与血清IL-8、hsCRP及TNF-α水平有关。
