Jakobiec F A, Perry H D, Harrison W, Krebs W
Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, New York.
Ophthalmology. 1989 Jul;96(7):1014-20. doi: 10.1016/s0161-6420(89)32799-0.
For 15 years, a 48-year-old woman had been aware of a pinkish translucent inferior epibulbar mass toward the fornix that was stationary in size. Light microscopic evaluation of the excised specimen showed that it was a gland-forming benign tumor. It originated from the surface epithelium by the downward invagination of tubular formations that underwent secondary and tertiary ramifications. The surface epithelium overlying the mass was not normal conjunctival squamous epithelium, but it was a modification in the form of a superficial layer of columnar to cuboidal cells surmounting several nuclei similar to the cells lining the subepithelial lumen-forming units. Electron microscopy showed that both the surface and tumor epithelium contained apical lacrimal-type zymogen granules and basilar whorls of rough-surfaced endoplasmic reticulum. Scattered myoepithelial cells were associated with the acinar-type epithelium of the tumor, and there were goblet cells intermixed. Neither light nor electron microscopy disclosed the presence of true ducts. The authors conclude that the lesion was a benign proliferation of lacrimal secretory-type cells and suggest the term "dacryoadenoma" for this previously undescribed entity.
15年来，一名48岁女性一直察觉到靠近穹窿部有一个粉红色半透明的眼球下穹窿肿物，其大小无变化。对切除标本进行光学显微镜评估显示，这是一个形成腺体的良性肿瘤。它起源于表面上皮，由管状结构向下内陷形成，并经历了二级和三级分支。肿物上方的表面上皮并非正常的结膜鳞状上皮，而是一种改变，表现为一层柱状至立方体细胞覆盖着几个核，类似于上皮下管腔形成单位内衬的细胞。电子显微镜显示，表面上皮和肿瘤上皮均含有顶端泪腺型酶原颗粒和基底糙面内质网的螺旋。散在的肌上皮细胞与肿瘤的腺泡型上皮相关，且有杯状细胞混杂其中。光学显微镜和电子显微镜均未发现真正导管的存在。作者得出结论，该病变是泪腺分泌型细胞的良性增殖，并建议将这个之前未描述过的实体称为“泪腺瘤”。
