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经右胸小切口与正中胸骨切开术行主动脉瓣置换术:倾向评分分析

Aortic valve replacement via right minithoracotomy versus median sternotomy: a propensity score analysis.

作者信息

Glower Donald D, Desai Bhargavi S, Hughes G Chad, Milano Carmelo A, Gaca Jeffrey G

机构信息

From the Department of Surgery, Duke University Medical Center, Durham, NC USA.

出版信息

Innovations (Phila). 2014 Mar-Apr;9(2):75-81; discussion 81. doi: 10.1097/IMI.0000000000000062.

Abstract

OBJECTIVE

The aim of this study was to define the relative role of a right minithoracotomy (RT) versus standard median sternotomy (ST) for open aortic valve replacement (AVR).

METHODS

A retrospective analysis was performed of all 1348 patients undergoing isolated, open AVR at a single institution during a 14-year period. Because relatively few patients were technically suitable for redo AVR with the RT approach (n = 20), all redo patients (n = 209) were excluded, leaving 1139 patients available for analysis. Patients converting from RT to ST approach (n = 15) were analyzed separately.

RESULTS

Relative to ST (n = 672), the RT patients (n = 452) were older with more stenosis but with more recent operation year, lower rate of congestive heart failure, higher ejection fraction, lower rate of endocarditis, and lower rate of renal disease than the ST AVR patients (all P < 0.0001). Right minithoracotomy AVR was associated with longer cardiopulmonary bypass times [157 (25) vs 131 (38), P = 0.0004] and clamp times [103 (20) vs 85 (27), P < 0.0001] but less transfusion (1.4 vs 3.4 U, P = 0.0003), less chest tube output (405 vs 950 mL, P < 0.0001), fewer reoperations for bleeding (0.4% vs 4%, P < 0.0001), shorter length of stay (6 vs 8 days, P = 0.03), and lower rate of atrial fibrillation (15% vs 20%, P = 0.03). Stroke, operative mortality, and survival were not significantly different between the groups.

CONCLUSIONS

Given the biases of retrospective propensity-adjusted analysis, these data suggest that RT AVR is a safe alternative to ST AVR in selected patients, with advantages of avoiding sternotomy with associated bleeding, transfusion, and delayed wound healing, at the expense of longer pump and clamp times.

摘要

目的

本研究旨在明确右胸小切口(RT)与标准正中开胸(ST)在开放性主动脉瓣置换术(AVR)中的相对作用。

方法

对一家机构在14年期间接受单纯开放性AVR的1348例患者进行回顾性分析。由于技术上适合采用RT方法进行再次AVR的患者相对较少(n = 20),所有再次手术患者(n = 209)均被排除,剩余1139例患者可供分析。从RT转为ST方法的患者(n = 15)单独进行分析。

结果

与ST组(n = 672)相比,RT组患者(n = 452)年龄更大,狭窄程度更高,但手术年份更近,充血性心力衰竭发生率更低,射血分数更高,心内膜炎发生率更低,肾病发生率更低(所有P < 0.0001)。右胸小切口AVR与更长的体外循环时间[157(25)对131(38),P = 0.0004]和夹闭时间[103(20)对85(27),P < 0.0001]相关,但输血更少(1.4对3.4单位,P = 0.0003),胸腔引流量更少(405对950 mL,P < 0.0001),因出血进行再次手术的次数更少(0.4%对4%,P < 0.0001),住院时间更短(6对8天,P = 0.03),房颤发生率更低(15%对20%,P = 0.03)。两组之间的卒中、手术死亡率和生存率无显著差异。

结论

鉴于回顾性倾向调整分析存在偏差,这些数据表明,在选定患者中,RT AVR是ST AVR的一种安全替代方法,具有避免开胸带来的相关出血、输血和伤口愈合延迟的优点,但代价是体外循环和夹闭时间更长。

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