Titarenko O T, Tikhodeev S A, Perova T L, Lipskaia E A
Vopr Med Khim. 1989 May-Jun;35(3):100-3.
Patterns of collagen metabolism were studied in 36 patients with hematogenic vertebral column osteomyelitis simultaneously with evaluation of C-reactive protein, haptoglobin and ceruloplasmin in blood and consideration of the clinico-morphological steps of the disease. Hyperhydroxyprolineuria proved to be a more informative evidence for inflammation in vertebral column as compared with the proteins of acute phase of inflammation importance of hydroxyproline measurement in biological fluids for evaluation of the osteomyelitis development was elevated as the inflammation activity decreased (which was estimated by content of the acute phase proteins).
对36例血源性脊柱骨髓炎患者的胶原代谢模式进行了研究，同时评估了血液中的C反应蛋白、触珠蛋白和铜蓝蛋白，并考虑了疾病的临床形态学分期。与炎症急性期蛋白相比，高羟脯氨酸尿症被证明是脊柱炎症更具信息价值的证据。随着炎症活动度降低（通过急性期蛋白含量评估），生物体液中羟脯氨酸测量对于评估骨髓炎发展的重要性增加。
