Paguigan Noemi D, Castillo Darryl Hannah B, Chichioco-Hernandez Christine L
Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City, Philippines.
Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City, Philippines.
Arq Gastroenterol. 2014 Jan-Mar;51(1):64-7. doi: 10.1590/s0004-28032014000100013.
Ulcer is the most common gastrointestinal disturbance resulting from an inadequate gastric mucosal defense. Several drugs are available in the market to address the disease; however, these drugs are associated with unnecessary side effects.
Previous research have confirmed the efficacy of plant extracts for possible treatment of the disease. This research aims to evaluate the anti-ulcer properties of medicinal plants.
Methanol extracts from the leaves of Intsia bijuga, Cynometra ramiflora, Tamarindus indica, Cassia javanica, Cassia fistula, Bauhini purpurea, Senna spectabilis, Senna siamea and Saraca thaipingensis were evaluated for their anti-ulcer activity using HCl-ethanol as ulcerogen.
All extracts showed inhibitory activity with I. bijuga, T. indica, S. spectabilis and S. thaipingensis exhibiting more than 50% inhibition. S. thaipingensis showed the highest activity at 80%. S. spectabilis and S. thaipingensis were partitioned further into hexane, ethyl acetate and aqueous fractions. The aqueous and ethyl acetate fractions of S. spectabilis showed significant increased in its activity while the hexane and ethyl acetate fractions of S. thaipingensis gave higher activity than its aqueous portions.
We conclude that plant extracts are potential sources of new anti-ulcer agents.
溃疡是由胃黏膜防御不足导致的最常见的胃肠道疾病。市场上有几种药物可用于治疗该疾病；然而，这些药物都伴有不必要的副作用。
先前的研究已证实植物提取物可能对该疾病具有治疗效果。本研究旨在评估药用植物的抗溃疡特性。
以盐酸 - 乙醇作为致溃疡剂，对大果水黄皮、小花鱼藤、罗望子、爪哇决明、腊肠树、紫花羊蹄甲、美丽决明、暹罗决明和太平无忧花叶片的甲醇提取物进行抗溃疡活性评估。
所有提取物均表现出抑制活性，大果水黄皮、罗望子、美丽决明和太平无忧花的抑制率超过50%。太平无忧花的活性最高，为80%。美丽决明和太平无忧花进一步分离为己烷、乙酸乙酯和水相部分。美丽决明的水相和乙酸乙酯部分活性显著增加，而太平无忧花的己烷和乙酸乙酯部分的活性高于其水相部分。
我们得出结论，植物提取物是新型抗溃疡药物的潜在来源。
