Lee D H, Wriedt C H, Kaufmann J C, Pelz D M, Fox A J, Vinuela F
Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
AJNR Am J Neuroradiol. 1989 Jul-Aug;10(4):773-6.
In ongoing research into potential embolic agents, three substances were evaluated for their effectiveness in occluding the pig rete. Selective injection of these agents produced varying degrees of occlusion, with the most effective a microfibrillar collagen hemostat in a 33% ethanol solution. Angiostat, a collagen particulate, did not produce rete occlusion, and all pigs injected with it developed adverse effects, including coma and apnea. Tisseel, a tissue sealant, produced partial rete occlusion, but was uniformly difficult to manage through long catheters, and its use was discontinued. Microfibrillar collagen hemostat with ethanol appears to have the greatest potential as an embolic agent in low-flow structures.
在对潜在栓塞剂的持续研究中，评估了三种物质封堵猪视网膜静脉网的效果。选择性注射这些物质产生了不同程度的封堵效果，最有效的是33%乙醇溶液中的微纤维胶原止血剂。胶原蛋白颗粒剂Angiostat未产生视网膜静脉网封堵效果，所有注射该物质的猪都出现了不良反应，包括昏迷和呼吸暂停。组织密封剂Tisseel产生了部分视网膜静脉网封堵效果，但通过长导管使用时始终难以操作，因此停止了使用。含乙醇的微纤维胶原止血剂似乎作为低血流结构中的栓塞剂具有最大潜力。
