Yuan Gao-Feng, Chen Xiao-E, Li Duo
College of Food and Medicine, Zhejiang Ocean University, Zhoushan 316022, China.
Food Funct. 2014 Jul 25;5(7):1360-8. doi: 10.1039/c4fo00037d.
Conjugated linolenic acid (CLNA) is a mixture of positional and geometric isomers of octadecatrienoic acid (α-linolenic acid, cis9,cis12,cis15-18:3 n-3) found in plant seeds. Three 8,10,12-18:3 isomers and four 9,11,13-18:3 isomers have been reported to occur naturally. CLNA isomers such as punicic acid, α-eleostearic acid and jacaric acid have been attributed to exhibit several health benefits that are largely based on animal and in vitro studies. This review has summarized and updated the evidence regarding the metabolism and bioactivities of CLNA isomers, and comprehensively discussed the recent studies on the effects of anti-carcinogenic, lipid metabolism regulation, anti-inflammatory, anti-obese and antioxidant activities of CLNA isomers. The available results may provide a potential application for CLNA isomers from natural sources, especially edible plant seeds, as effective functional food ingredients and dietary supplements for the above mentioned disease management. Further research, especially human randomized clinical trials, is warranted to investigate the detailed physiological effects, bioactivity and molecular mechanism of CLNA.
共轭亚麻酸（CLNA）是植物种子中发现的十八碳三烯酸（α-亚麻酸，顺式9，顺式12，顺式15 - 18:3 n - 3）的位置和几何异构体的混合物。据报道，有三种8,10,12 - 18:3异构体和四种9,11,13 - 18:3异构体天然存在。诸如石榴酸、α-桐酸和紫铆酸等CLNA异构体已被认为具有多种健康益处，这些益处很大程度上基于动物和体外研究。本综述总结并更新了有关CLNA异构体代谢和生物活性的证据，并全面讨论了CLNA异构体在抗癌、脂质代谢调节、抗炎、抗肥胖和抗氧化活性方面作用的最新研究。现有结果可能为天然来源的CLNA异构体，特别是可食用植物种子，作为上述疾病管理的有效功能食品成分和膳食补充剂提供潜在应用。有必要进行进一步研究，尤其是人体随机临床试验，以研究CLNA的详细生理效应、生物活性和分子机制。
