Suppr超能文献

肠道微生物群驱动的脂质代谢:机制及其在养猪生产中的应用

Gut-Microbiota-Driven Lipid Metabolism: Mechanisms and Applications in Swine Production.

作者信息

Xiong Shuqi

机构信息

National Key Laboratory of Pig Genetic Improvement and Germplasm Innovation, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

出版信息

Metabolites. 2025 Apr 4;15(4):248. doi: 10.3390/metabo15040248.

Abstract

The gut microbiota plays a pivotal role in host physiology through metabolite production, with lipids serving as essential biomolecules for cellular structure, metabolism, and signaling. This review aims to elucidate the interactions between gut microbiota and lipid metabolism and their implications for enhancing swine production. We systematically analyzed current literature on microbial lipid metabolism, focusing on mechanistic studies on microbiota-lipid interactions, key regulatory pathways in microbial lipid metabolism, and multi-omics evidence (metagenomic/metabolomic) from swine models. This review outlines the structural and functional roles of lipids in bacterial membranes and examines the influence of gut microbiota on the metabolism of key lipid classes, including cholesterol, bile acids, choline, sphingolipids, and fatty acids. Additionally, we explore the potential applications of microbial lipid metabolism in enhancing swine production performance. Our analysis establishes a scientific framework for microbiota-based strategies to optimize lipid metabolism. The findings highlight potential interventions to improve livestock productivity through targeted manipulation of gut microbial communities.

摘要

肠道微生物群通过代谢产物的产生在宿主生理中发挥关键作用,脂质是细胞结构、代谢和信号传导的重要生物分子。本综述旨在阐明肠道微生物群与脂质代谢之间的相互作用及其对提高猪生产性能的影响。我们系统地分析了当前关于微生物脂质代谢的文献,重点关注微生物与脂质相互作用的机制研究、微生物脂质代谢的关键调控途径以及来自猪模型的多组学证据(宏基因组学/代谢组学)。本综述概述了脂质在细菌膜中的结构和功能作用,并研究了肠道微生物群对关键脂质类别的代谢影响,包括胆固醇、胆汁酸、胆碱、鞘脂和脂肪酸。此外,我们还探讨了微生物脂质代谢在提高猪生产性能方面的潜在应用。我们的分析为基于微生物群的优化脂质代谢策略建立了科学框架。研究结果突出了通过有针对性地操纵肠道微生物群落来提高家畜生产力的潜在干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2707/12029090/f92aee2c0d41/metabolites-15-00248-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验