Department of Clinical Sciences, Lund University, Skåne University hospital, Malmö, Sweden.
Department of Clinical Sciences, Lund University, Skåne University hospital, Malmö, Sweden Department of Cardiology, Lund University, Skåne University Hospital, Lund, Sweden Program of Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Heart. 2014 Jul;100(14):1119-24. doi: 10.1136/heartjnl-2013-305028. Epub 2014 Apr 23.
High red cell distribution width (RDW) is a strong prognostic factor in patients with cardiovascular disease. We investigated the association between RDW and incidence of acute coronary events (CEs) and fatal outcome in subjects who subsequently experienced a first CE.
RDW was measured in 26 820 subjects (aged 45-73 years, 61.6% women), without history of myocardial infarction or stroke, who participated in the Malmö Diet and Cancer study during 1991-1996. Cox proportional hazards model was used to analyse the association between RDW and CE. During a mean follow-up of 14 years, 1995 subjects had a first CE, of which 415 subjects died on the same day as the CE (fatal on day 1), another 86 died within 28 days (fatal in 28 days) and 1494 were non-fatal (survived >28 days). After adjustment for risk factors, baseline RDW was significantly associated with incidence of fatal CE (HR 1.82, CI 1.35 to 2.44) but not with non-fatal CE (HR 0.96, CI 0.82 to 1.12). Among all subjects with a CE during follow-up, the proportion who died on day 1 was 13.7%, 18.2%, 22.5% and 26.7%, respectively, for first, second, third and fourth quartiles of RDW.
In this population-based study of subjects without history of CE or stroke, high RDW was associated with increased incidence of fatal CE. No relationship was observed for incidence of non-fatal CE.
高红细胞分布宽度（RDW）是心血管疾病患者的一个强有力的预后因素。我们研究了 RDW 与急性冠状动脉事件（CE）的发生以及随后发生首次 CE 的患者的致命结局之间的关系。
在 1991 年至 1996 年期间参加马尔默饮食与癌症研究的 26820 名受试者（年龄 45-73 岁，61.6%为女性）中测量了 RDW。使用 Cox 比例风险模型分析 RDW 与 CE 之间的关系。在平均 14 年的随访期间，1995 名受试者发生了首次 CE，其中 415 名受试者在 CE 当天死亡（第 1 天死亡），86 名受试者在 28 天内死亡（28 天内死亡），1494 名受试者非致命（存活>28 天）。在调整危险因素后，基线 RDW 与致命性 CE 的发生显著相关（HR 1.82，CI 1.35 至 2.44），但与非致命性 CE 无关（HR 0.96，CI 0.82 至 1.12）。在随访期间发生 CE 的所有受试者中，RDW 的第一、第二、第三和第四四分位数的第 1 天死亡比例分别为 13.7%、18.2%、22.5%和 26.7%。
在这项基于人群的无 CE 或中风史受试者研究中，高 RDW 与致命性 CE 的发生率增加相关。未观察到非致命性 CE 发生率的关系。
