免疫脾细胞和免疫核糖核酸对伯氏疟原虫保护作用的比较评价。

Comparative evaluation of the protective effect of immune spleen cells and immune RNA against Plasmodium berghei.

作者信息

Khullar N, Parashar A, Sehgal S

机构信息

Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Ann Trop Med Parasitol. 1988 Dec;82(6):519-26. doi: 10.1080/00034983.1988.11812287.

DOI:10.1080/00034983.1988.11812287

PMID:2476085

Abstract

Earlier studies from this laboratory indicated that passive transfer of viable or frozen-thawed cells from spleens and lymph nodes of immune mice resulted in a significant protective immunity against Plasmodium berghei in syngeneic recipients. To assess whether immune RNA played a role in conferring such protection, experiments were designed wherein immune RNA was isolated from immune monkeys, rats and mice and transferred to normal mice. The effect of transfer was assessed by challenging RNA-primed animals with Plasmodium berghei. Results indicated that immune RNA failed to confer resistance against P. berghei both in syngeneic and in heterologous systems.

摘要

该实验室早期的研究表明，将来自免疫小鼠脾脏和淋巴结的活细胞或冻融细胞进行被动转移，可使同基因受体对伯氏疟原虫产生显著的保护性免疫。为了评估免疫RNA在提供这种保护中是否起作用，设计了实验，从免疫的猴、大鼠和小鼠中分离免疫RNA并转移到正常小鼠体内。通过用伯氏疟原虫攻击经RNA致敏的动物来评估转移的效果。结果表明，免疫RNA在同基因和异源系统中均未能赋予对伯氏疟原虫的抗性。