大鼠对伯氏疟原虫的免疫：被动血清转移及脾脏的作用
Immunity to Plasmodium berghei in rats: passive serum transfer and role of the spleen.
作者信息
Brown I N, Phillips R S
出版信息
Infect Immun. 1974 Dec;10(6):1213-8. doi: 10.1128/iai.10.6.1213-1218.1974.
Abstract
Pools of rat antiserum to Plasmodium berghei had different levels of protective activity as assessed by a passive transfer test. Preincubation of parasite inocula with an effective pool before injection did not significantly enhance protective activity. Removal of the antiserum from preincubated parasite inocula abolished the bulk of protective activity. Similarly, antiserum effective in intact animals was largely ineffective in splenectomized recipients. These experiments suggest a minimal role for antibody acting directly on P. berghei-parasitized cells and reemphasize a significant role for the spleen in immunity to this plasmodium.
摘要
通过被动转移试验评估，针对伯氏疟原虫的大鼠抗血清池具有不同水平的保护活性。在注射前将寄生虫接种物与有效抗血清池进行预温育，并未显著增强保护活性。从预温育的寄生虫接种物中去除抗血清，消除了大部分保护活性。同样，在完整动物中有效的抗血清在脾切除的受体中大多无效。这些实验表明抗体直接作用于被伯氏疟原虫寄生的细胞的作用最小，并再次强调了脾脏在针对这种疟原虫的免疫中的重要作用。
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